Reviewed on 1/14/2022

Brand Name: Artane, Trihex

Generic Name: Trihexyphenidyl

Drug Class: Antiparkinson Agents, Anticholinergics

What Is Trihexyphenidyl and How Does It Work?

Trihexyphenidyl is a prescription medication used to treat Parkinson's Disease and Drug-induced Extrapyramidal Symptoms.

  • Trihexyphenidyl is available under the following different brand names: Artane, Trihex

What Are Dosages of Trihexyphenidyl?

Adult dosage


  • 2mg
  • 5mg


  • 0.4mg/mL

Parkinson Disease

Adult dosage

  • Initial: 1 mg orally first day, then increase by 2 mg every 3-5 days until dose reaches 6-10 mg/day
  • Maintenance: 5-15 mg/day orally divided every 6-8 hours
  • Use SR product once stabilized on regular release product; when used with levodopa, generally use 3-6 mg/day in divided doses

Drug-induced Extrapyramidal Symptoms

Adult dosage

  • 1 mg/day orally initially; increase as necessary to maintenance range of 5-15 mg/day orally divided every 6-8 hours

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”.

What Are Side Effects Associated with Using Trihexyphenidyl?

Common side effects of Trihexyphenidyl include:

Serious side effects of Trihexyphenidyl include:

Rare side effects of Trihexyphenidyl include:

  • none 
This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.


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What Other Drugs Interact with Trihexyphenidyl?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

  • Trihexyphenidyl has severe interactions with no other drugs.
  • Trihexyphenidyl has serious interactions with the following drugs:
    • glucagon
    • glucagon intranasal
    • glycopyrronium tosylate topical 
    • revefenacin
    • secretin
    • umeclidinium bromide/vilanterol inhaled
  • Trihexyphenidyl has moderate interactions with at least 69 other drugs.
  • Trihexyphenidyl has minor interactions with the following drug:
    • levodopa 

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings And Precautions for Trihexyphenidyl?


Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Trihexyphenidyl?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Trihexyphenidyl?”


Pregnancy and Lactation

  • Use with caution if the benefits outweigh the risks during pregnancy. 
  • Lactation: no data; may inhibit lactation.
Medscape. Trihexyphenidyl.

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