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Valproic Acid

Brand Name: Depakene, Stavzor, Depacon

Generic Name: Valproic Acid

Drug Class: Anticonvulsants

What Is Valproic Acid and How Does It Work?

Valproic acid is an antiepileptic used to treat various types of seizure disorders. Valproic acid is sometimes used together with other seizure medications.

Valproic acid is available under the following different brand names: Depakene, Stavzor, and Depacon.

Dosages of Valproic Acid

Adult and Pediatric Dosage Forms and Strengths

Capsule (Depakene)

  • 250 mg

Capsule, delayed-release (Stavzor)

  • 125 mg
  • 250 mg
  • 500 mg

Syrup (Depakene)

  • 250 mg/5mL

Injectable solution (Depacon as valproate sodium)

  • 100 mg/5mL

Dosage Considerations – Should be Given as Follows:

Complex Partial Seizures

Indicated as monotherapy and adjunctive therapy for complex partial seizures that occur either in isolation or in association with other types of seizures

Adult

  • Intravenous (IV) (valproate sodium): 10-15 mg/kg/day IV divided every 12 hours infused over 1 hour; maximum dose 60 mg/kg/day; do not exceed 14 days (switch to orally as soon as possible)
  • Oral: 10-15 mg/kg/day orally initially; increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day

Pediatric

  • Intravenous (IV) (valproate sodium): 10-15 mg/kg/day IV divided every 12 hours infused over 1 hour; maximum dose 60 mg/kg/day; do not exceed 14 days (switch to orally as soon as possible)
  • Oral: (Depakene or Stavzor): 10-15 mg/kg/day orally initially; increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day
  • Children under 10 years: Safety and efficacy not established

Simple and Complex Absence Seizures

Also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types that include absence seizures

Adult

  • Intravenous (IV) (valproate sodium): 10-15 mg/kg/day IV divided every 12 hours infused over 1 hour; maximum dose 60 mg/kg/day; do not exceed 14 days (switch to oral as soon as possible)
  • Oral (Depakene, Stavzor): 15 mg/kg/day orally initially, divided every 6-12 hours; increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day

Pediatric

Children 10 years and older

  • Intravenous (IV) (valproate sodium): 10-15 mg/kg/day IV divided every 12 hours infused over 1 hour; maximum dose 60 mg/kg/day; do not exceed 14 days (switch to oral as soon as possible)
  • Stavzor: 250 mg orally every 12 hours; adjust dose based on clinical response up to 1000 mg/day

Children under 10 years: Safety and efficacy not established

Migraine

  • Indicated for prophylaxis of migraine headaches; there is no evidence of use for acute treatment
  • Stavzor: 250 mg orally every 12 hours; adjust dose based on clinical response, not to exceed 1000 mg/day

Bipolar Mania

  • Indicated for treatment of manic episodes associated with bipolar disorder
  • Stavzor: 750 mg/day orally in divided doses; adjust dose as rapidly as possible to desired therapeutic effect; not to exceed 60 mg/kg/day

Dosage Modifications

Renal impairment

  • No adjustment necessary; protein binding is reduced and may cause measurement of total valproate concentrations to be inaccurate

Hepatic impairment

  • Administer lower doses
  • Contraindicated in severe impairment

Dosing Considerations

Monitor liver function tests (LFT's)

Therapeutic range

  • Low serum albumin levels may cause an increase in unbound drug (while total concentration may appear normal)
  • Epilepsy: 50-100 mcg/mL total valproate
  • Mania: 50-125 mcg/mL total valproate
Medically Reviewed by a Doctor on 1/11/2018



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