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Pyridoxine (Antidote)

Reviewed on 4/20/2020

What Is Pyridoxine (Antidote) and How Does It Work?

Brand Name: vitamin B6 (Antidote)
Generic Name: Pyridoxine (Antidote)
Drug Class: Antidotes, Other

Pyridoxine (antidote) is used for isoniazid (INH) overdose, prevention of drug-induced neuritis, ethylene glycol toxicity, gyromitrin poisoning, toxicity due cycloserine overdose, penicillamine overdose, hydrazine ingestion, or Gyromitra mushrooms (contains monomethylhydrazine precursors). Pyridoxine (antidote) may be effective in ginkgo biloba seed toxicity.

Pyridoxine (antidote) is available under the following different brand names: vitamin B6 (Antidote).

Dosages of Pyridoxine (Antidote):

Dosage Forms and Strengths

Injectable Solution

  • 100mg/mL

Tablets

  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg

Tablets, Sustained Release

  • 500mg

Dosage Considerations – Should be Given as Follows:

Isoniazid (INH) Overdose

  • 1 g per gram INH ingested or 70 mg/kg intravenously (IV) if unknown, may require 1 g every 30 minutes; not to exceed 5 g with unclear history

Prevention of Drug-Induced Neuritis

  • Adult: 10-50 mg/day orally (penicillamine or INH); 100-300 mg/day (cycloserine)
  • Pediatric: 1-2 mg/kg/24 hours orally

Ethylene Glycol Toxicity

  • Adult: 100 mg IV every 6 hours for 2 days
  • Pediatric: 1-2 mg/kg IV during first 24 hours

Gyromitrin Poisoning

  • 25 mg/kg IV infusion over 15-30 minutes; repeat as needed up to 15-20 g/day
  • Use in conjunction with benzodiazepines, phenobarbital

Other Indications and Uses

  • Toxicity due cycloserine overdose, penicillamine overdose, hydrazine ingestion, or Gyromitra mushrooms (contains monomethylhydrazine precursors)
  • May be effective in ginkgo biloba seed toxicity

What Are Side Effects Associated with Using Pyridoxine (Antidote)?

Side effects of pyridoxine (antidote) include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

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What Other Drugs Interact with Pyridoxine (Antidote)?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Pyridoxine (antidote) has no listed severe interactions with other drugs.
 

Serious interactions of pyridoxine (antidote) include:

  • altretamine
  • cisplatin

Moderate interactions of pyridoxine (antidote) include:

  • azithromycin
  • clarithromycin
  • erythromycin base
  • erythromycin ethylsuccinate
  • erythromycin lactobionate
  • erythromycin stearate
  • levodopa
  • roxithromycin

Pyridoxine (antidote) has mild interactions with at least 65 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Pyridoxine (Antidote)? 

Warnings
 

This medication contains pyridoxine (antidote). Do not take vitamin B6 (Antidote) if you are allergic to pyridoxine (antidote) or any ingredients contained in this drug.


Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • No information available

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Pyridoxine (Antidote)?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Pyridoxine (Antidote)?”

Cautions

  • No information available

Pregnancy and Lactation

Pyridoxine (antidote) is generally acceptable for use during pregnancy. Controlled studies in pregnant women show no evidence of fetal risk.

No information is available regarding use of pyridoxine (antidote) in lactating women. Consult your doctor before breastfeeding.

References
https://reference.medscape.com/drug/vitamin-b6-antidote-pyridoxine-antidote-343748

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