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Last reviewed on RxList: 10/27/2016
Corgard Side Effects Center

Last reviewed on RxList 11/11/2016

Corgard (nadolol) is a beta-blocker used to treat angina (chest pain) and hypertension (high blood pressure). Corgard is available in generic form. Common side effects of Corgard include:

  • dizziness,
  • drowsiness,
  • weakness,
  • fatigue,
  • spinning sensation (vertigo),
  • tired feeling,
  • nausea,
  • diarrhea,
  • constipation,
  • upset stomach,
  • bloating,
  • gas, and
  • tingly feeling.

Tell your doctor if you have unlikely but serious side effects of Corgard including:

  • bluish color of the fingers/toes/nails,
  • hair loss (reversible),
  • mental/mood changes (e.g., depression, confusion, memory problems),
  • numbness and tingling,
  • decreased sexual ability,
  • swelling of the ankles or feet,
  • severe tiredness,
  • vision changes,
  • wheezing, and
  • unexplained or sudden weight gain.

Dosage of Corgard is individualized. The usual initial dose to treat angina or hypertension is 40 mg once daily. Dosage may be gradually increased. The usual maintenance dose is 40 or 80 mg administered once daily. Corgard may interact with allergy treatments or allergy skin-testing, clonidine, MAO inhibitors, diabetes medications, heart medications, medicine for asthma or other breathing disorders, cold medicines, stimulant medicines, or diet pills. Tell your doctor all medications you are taking. Corgard should be used only when prescribed during pregnancy. If used near the time of delivery, the newborn may have problems such as slow heart rate or low blood sugar. Tell your doctor if you notice a slow heart rate or signs of low blood sugar (e.g., shakiness, sweating) in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Corgard (nadolol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Corgard Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • slow or uneven heartbeats;
  • numbness or cold feeling;
  • feeling like you might pass out;
  • feeling short of breath, even with mild exertion;
  • swelling or rapid weight gain;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • hallucinations, behavior changes; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dizziness, spinning sensation;
  • tired feeling;
  • mild nausea, diarrhea, constipation, upset stomach, bloating, gas; or
  • tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Corgard (Nadolol)

Corgard Professional Information


Most adverse effects have been mild and transient and have rarely required withdrawal of therapy.


Bradycardia with heart rates of less than 60 beats per minute occurs commonly, and heart rates below 40 beats per minute and/or symptomatic bradycardia were seen in about 2 of 100 patients. Symptoms of peripheral vascular insufficiency, usually of the Raynaud type, have occurred in approximately 2 of 100 patients. Cardiac failure, hypotension, and rhythm/conduction disturbances have each occurred in about 1 of 100 patients. Single instances of first degree and third degree heart block have been reported; intensification of AV block is a known effect of beta-blockers (see also CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS).

Central Nervous System

Dizziness or fatigue has been reported in approximately 2 of 100 patients; paresthesias, sedation, and change in behavior have each been reported in approximately 6 of 1000 patients.


Bronchospasm has been reported in approximately 1 of 1000 patients (see CONTRAINDICATIONS and WARNINGS).


Nausea, diarrhea, abdominal discomfort, constipation, vomiting, indigestion, anorexia, bloating, and flatulence have been reported in 1 to 5 of 1000 patients.


Each of the following has been reported in 1 to 5 of 1000 patients: rash; pruritus; headache; dry mouth, eyes, or skin; impotence or decreased libido; facial swelling; weight gain; slurred speech; cough; nasal stuffiness; sweating; tinnitus; blurred vision. Reversible alopecia has been reported infrequently.

The following adverse reactions have been reported in patients taking nadolol and/or other betaadrenergic blocking agents, but no causal relationship to nadolol has been established.

Central Nervous System

Reversible mental depression progressing to catatonia; visual disturbances; hallucinations; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability with slightly clouded sensorium, and decreased performance on neuropsychometrics.


Mesenteric arterial thrombosis; ischemic colitis; elevated liver enzymes.


Agranulocytosis; thrombocytopenic or nonthrombocytopenic purpura.


Fever combined with aching and sore throat; laryngospasm; respiratory distress.


Pemphigoid rash; hypertensive reaction in patients with pheochromocytoma; sleep disturbances; Peyronie's disease.

The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with nadolol.

Read the entire FDA prescribing information for Corgard (Nadolol)

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