Corlopam

Last updated on RxList: 1/22/2021
Corlopam Side Effects Center

What Is Corlopam?

Corlopam (fenoldopam mesylate) Injection is a dopamine receptor agonist (vasodilator) used for in-hospital, short-term (up to 48 hours) management of severe high blood pressure (hypertension) when rapid, but quickly reversible, emergency reduction of blood pressure is indicated. Corlopam is available in generic form.

What Are Side Effects of Corlopam?

Common side effects of Corlopam include headache, flushing (warmth, redness, or tingly feeling, particularly in the face and neck), nausea, low blood pressure (hypotension), fast heartbeat, and low blood potassium.

Dosage for Corlopam?

The drug dose rate of Corlopam is individualized for each patient according to body weight and according to the desired rapidity and extent of pharmacodynamic effect.

What Drugs, Substances, or Supplements Interact with Corlopam?

Corlopam may interact with other drugs. Tell your doctor all medications and supplements you use.

Corlopam During Pregnancy and Breastfeeding

During pregnancy, Corlopam should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Corlopam (fenoldopam mesylate) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Corlopam Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Fenoldopam may cause you to have fast heartbeats, or a light-headed feeling (like you might pass out).

After treatment, call your doctor at once if you have:

  • vision changes, severe headache;
  • swelling, rapid weight gain;
  • shortness of breath;
  • pounding in your neck or ears; or
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

  • feeling light-headed;
  • headache;
  • nausea; or
  • flushing (sudden warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Corlopam (Fenoldopam Mesylate Injection)

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Corlopam Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The most common reactions associated with fenoldopam use are headache, cutaneous dilation (flushing), nausea, and hypotension, each reported in more than 5% of patients.

Adverse reactions occurring more than once in any dosing group (once if potentially important or plausibly drug-related) in the fixed-dose constantinfusion studies are presented in Table 3. There was no clear dose relationship, except possibly for headache, nausea, flushing.

Table 3: Adverse reactions in fixed-dose studies occurring in > 5% of subjects on fenoldopam

EventPlacebo
(n = 7)
Fenoldopam
(n = 125)
n (%)n (%)
Headache1 (14%)30 (24%)
Nausea015 (12%)
Vomiting07 (6%)
Injection site reaction09 (7%)
Electrocardiogram T wave inversion07 (6%)

The following additional adverse reactions were observed more frequently in patients treated with fenoldopam

Incidence 0.5% to 5%

Metabolism and Nutrition Disorders - Hypokalemia

Psychiatric Disorders - Nervousness/Anxiety, insomnia

Nervous System Disorders - Dizziness

Cardiac Disorders - Extrasystoles, palpitations, cardiac failure, ischemic heart disease, myocardial infarction, angina pectoris, tachycardia

Gastrointestinal Disorders - Abdominal pain

Skin and Subcutaneous Tissue Disorders - Hyperhidrosis

Musculoskeletal and Connective Tissue Disorders -Muscle spasms

Renal and Urinary Disorders - Oliguria

General Disorders and Administration Site Conditions -Chest pain, pyrexia

Investigations - Blood urea increased, blood creatinine increased, blood glucose increased, transaminases increased, blood lactate dehydrogenase increased

Post-Marketing Experience

The following adverse reactions have been identified during post approval use of Corlopam. Because these reactions are reported voluntarily from a population of uncertain size, it is difficult to reliably estimate their frequency or evaluate a causal relationship to drug exposure. Voluntary reports of adverse reactions temporally associated with Corlopam that have been received since market introduction and that may have no causal relationship with the drug include the following:

Cardiac Disorders - Cardiogenic shock

Vascular Disorders - Hypotension

Gastrointestinal Disorders - Abdominal distension

Investigations - Electrocardiogram ST segment depression, oxygen saturation decreased

Read the entire FDA prescribing information for Corlopam (Fenoldopam Mesylate Injection)

© Corlopam Patient Information is supplied by Cerner Multum, Inc. and Corlopam Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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