Corphedra Side Effects Center

Last updated on RxList: 1/18/2023
Corphedra Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Corphedra?

Corphedra (ephedrine sulfate injection), for intravenous use is an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia.

What Are Side Effects of Corphedra?

Corphedra may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • high blood pressure,
  • sudden numbness or weakness in the face, arm, or leg (especially on one side of the body),
  • sudden confusion,
  • trouble speaking,
  • difficulty understanding speech,
  • dizziness,
  • loss of balance,
  • lack of coordination,
  • trouble walking,  
  • chest pain or pressure,
  • weakness,
  • lightheadedness,
  • fainting,
  • pain in the jaw, neck, or back,
  • shortness of breath,
  • seizure,
  • irregular heartbeat, and
  • death

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Corphedra include:

  • nausea,
  • vomiting, and
  • fast heart rate.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Corphedra

The dose of Corphedra to treat hypotension developing during anesthesia is a bolus intravenous injection of 5 to 10 mg as needed, not to exceed 50 mg.

What Drugs, Substances, or Supplements Interact with Corphedra?

Corphedra may interact with clonidine, oxytocin and oxytocic drugs, propofol, monoamine oxidase inhibitors (MAOIs), atropine, alpha-blockers, beta blockers, reserpine, quinidine, mephentermine, guanethidine, rocuronium, epidural anesthesia, theophylline, and cardiac glycosides. Tell your doctor all medications and supplements you use.

Corphedra During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Corphedra; it is unknown how it will affect a fetus. It is unknown if Corphedra passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Corphedra (ephedrine sulfate injection), for Intravenous Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Low Blood Pressure (Hypotension): Symptoms, Signs, Causes See Slideshow
Corphedra Professional Information


The following adverse reactions associated with the use of ephedrine sulfate were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.

Gastrointestinal disorders: Nausea, vomiting

Cardiac disorders: Tachycardia, palpitations (thumping heart), reactive hypertension, bradycardia, ventricular ectopics, R-R variability

Nervous system disorders: Dizziness

Psychiatric disorders: Restlessness

For medical advice about adverse reactions, contact your medical professional. To report SUSPECTED ADVERSE REACTIONS, contact Par Pharmaceutical at 1-800-8289393 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Corphedra (Ephedrine Sulfate)

© Corphedra Patient Information is supplied by Cerner Multum, Inc. and Corphedra Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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