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Cortisporin Cream

Last reviewed on RxList: 6/21/2017
Cortisporin Cream Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/21/2017

Cortisporin Cream (neomycin and polymyxin B sulfates and hydrocortisone acetate cream) is a topical antibacterial cream used to treat skin lesions (such as psoriasis, or dermatitis) with secondary infection. Common side effects of Cortisporin Cream include:

  • burning
  • itching
  • irritation
  • dryness
  • infection of hair follicles
  • increase in body hair
  • acne
  • skin discoloration
  • dermatitis
  • rash around the mouth
  • breaking down of skin tissue (maceration)
  • secondary infection
  • thinning skin
  • stretch marks, or
  • rash

Apply a small quantity dose of Cortisporin Cream 2 to 4 times daily, as required. The cream should, if conditions permit, be gently rubbed into the affected areas. Cortisporin Cream may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Cortisporin Cream should be used only if prescribed. Hydrocortisone acetate passes into breast milk when taken by mouth. Consult your doctor before breastfeeding.

Our Cortisporin Cream (neomycin and polymyxin B sulfates and hydrocortisone acetate cream) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cortisporin Cream Professional Information


Neomycin occasionally causes skin sensitization. Ototoxicity and nephrotoxicity have also been reported (see WARNINGS). Adverse reactions have occurred with topical use of antibiotic combinations including neomycin and polymyxin B. Exact incidence figures are not available since no denominator of treated patients is available. The reaction occurring most often is allergic sensitization. In one clinical study, using a 20% neomycin patch, neomycin-induced allergic skin reactions occurred in two of 2,175 (0.09%) individuals in the general population.1 In another study, the incidence was found to be approximately 1%.2

The following local adverse reactions have been reported with topical corticosteroids, especially under occlusive dressings: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

When steroid preparations are used for long periods of time in intertriginous areas or over extensive body areas, with or without occlusive non-permeable dressings, striae may occur; also there exists the possibility of systemic side effects when steroid prepa- rations are used over large areas or for a long period of time.

Read the entire FDA prescribing information for Cortisporin Cream (Hydrocortisone, Neomycin, Polymyxin B)

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© Cortisporin Cream Patient Information is supplied by Cerner Multum, Inc. and Cortisporin Cream Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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