Cortone

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 11/9/2021
Cortone Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Cortone?

Cortone (cortisone acetate) is a glucocorticoid used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders. The brand name Cortone is discontinued, but generic versions may be available.

What Are Side Effects of Cortone?

Common side effects of Cortone (cortisone acetate) include:

  • insomnia,
  • mood changes,
  • acne,
  • dry skin,
  • thinning skin,
  • bruising or discoloration,
  • slow wound healing,
  • increased sweating,
  • headache,
  • dizziness,
  • spinning sensation,
  • nausea,
  • stomach pain,
  • bloating, or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Tell your doctor if you have unlikely but serious side effects of Cortone (cortisone acetate) including:

  • black stools,
  • bone or joint pain,
  • easy bruising or bleeding,
  • fast/pounding/irregular heartbeat,
  • increased thirst or urination,
  • muscle pain,
  • persistent weight gain,
  • puffy face,
  • seizures,
  • signs of infection (e.g., fever, persistent sore throat),
  • swelling of the ankles or feet,
  • thinning skin,
  • trouble breathing,
  • unusual hair growth,
  • unusual skin growths,
  • vision changes,
  • vomit that looks like coffee grounds, or
  • weakness.

Dosage for Cortone

The initial dosage of cortisone acetate may vary from 25 to 300 mg per day depending on the specific disease entity being treated.

What Drugs, Substances, or Supplements Interact with Cortone?

Cortisone acetate may interact with aspirin, diuretic, blood thinners, cyclosporine, insulin or oral diabetes medications, ketoconazole, rifampin, seizure medications, and other drugs. Tell your doctor all medications and supplements you use. It is unknown if cortisone acetate will harm a fetus.

Cortone During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Cortisone can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our cortisone acetate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

About how much does an adult human brain weigh? See Answer
Cortone Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blurred vision, eye pain or redness, seeing halos around lights;
  • swelling, rapid weight gain, feeling short of breath;
  • unusual changes in mood or behavior;
  • skin lesions;
  • sudden unusual pain in a bone or joint;
  • severe headaches, ringing in your ears, pain behind your eyes;
  • stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting; or
  • low blood potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Cortisone can affect growth in children. Tell your doctor if your child is not growing at a normal rate.

Common side effects may include:

  • high blood pressure;
  • muscle pain or weakness;
  • sleep problems (insomnia), mood changes;
  • thinning skin, bruising or discoloration;
  • increased sweating;
  • headache, dizziness, spinning sensation;
  • stomach pain, bloating; or
  • slow wound healing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cortone (Cortisone Acetate)

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Cortone Professional Information

SIDE EFFECTS

Fluid and electrolyte disturbances

Sodium retention

Potassium loss

Fluid retention

Hypokalemic alkalosis

Congestive heart failure in susceptible patients

Hypertension

Musculoskeletal

Muscle weakness

Vertebral compression fractures

Steroid myopathy

Aseptic necrosis of femoral and humeral heads

Loss of muscle mass

Osteoporosis

Tendon rupture, particularly of the Achilles tendon

Pathologic fracture of long bones

Gastrointestinal

Peptic ulcer with possible perforation and hemorrhage

Abdominal distention

Ulcerative esophagitis

Pancreatitis

Increases in alanine transaminase (ALT, SGPT), aspartate transaminase (AST, SGOT) and alkaline phosphatase have been observed following corticosteroid treatment. These changes are usually small, not associated with any clinical syndrome and are reversible upon discontinuation.

Dermatologic

Impaired wound healing

Facial erythema

Thin fragile skin

Increased sweating

Petechiae and ecchymoses

May suppress reactions to skin tests

Neurological

Increased intracranial pressure with papil-ledema (pseudotumor cerebri) usually after treatment

Convulsions

Vertigo

Headache

Endocrine

Menstrual irregularities

Suppression of growth in children

Development of Cushingoid state

Decreased carbohydrate tolerance

Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness

Manifestations of latent diabetes mellitus Increased requirements for insulin or oral hypoglycemic agents in diabetics

Ophthalmic

Posterior subcapsular cataracts Glaucoma

Increased intraocular pressure Exophthalmos

Metabolic

Negative nitrogen balance due to protein catabolism

Read the entire FDA prescribing information for Cortone (Cortisone Acetate)

© Cortone Patient Information is supplied by Cerner Multum, Inc. and Cortone Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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