Medical Editor: John P. Cunha, DO, FACOEP
Cortrosyn (cosyntropin) for Injection is a man-made portion of a certain natural substance made by the body (ACTH) used to diagnose adrenal gland problems (e.g., Addison's disease, insufficiency due to corticosteroid use, pituitary tumor). Cortrosyn is available in generic form. Common side effects of Cortrosyn include minor irritation at the injection site (e.g., redness, swelling, rash), rapid or slowed heart rate, high blood pressure, and swelling in limbs.
When given as an intravenous infusion, Cortrosyn in a 0.25 mg dose may be added to glucose or saline solutions and given at the rate of approximately 40 micrograms per hour over a 6-hour period. Cortrosyn may interact with cortisone, estrogen, hydrocortisone, spironolactone, or diuretics. Tell your doctor all medications and supplements you use. During pregnancy, Cortrosyn should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Cortrosyn (cosyntropin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Cortrosyn (Cosyntropin)
Since CORTROSYN™ (cosyntropin) for Injection is intended for diagnostic and not therapeutic use, adverse reactions other than a rare hypersensitivity reaction are not anticipated. A rare hypersensitivity reaction usually associated with a pre-existing allergic disease and/or a previous reaction to natural ACTH is possible. Symptoms may include slight whealing with splotchy erythema at the injection site. There have been rare reports of anaphylactic reaction. The following adverse reactions have been reported in patients after the administration of CORTROSYN™ and the association has been neither confirmed nor refuted:
Read the entire FDA prescribing information for Cortrosyn (Cosyntropin)