Cortrosyn Side Effects Center

Last updated on RxList: 12/1/2022
Cortrosyn Side Effects Center

What Is Cortrosyn?

Cortrosyn (cosyntropin) for Injection is a man-made portion of a certain natural substance made by the body (ACTH) used to diagnose adrenal gland problems (e.g., Addison's disease, insufficiency due to corticosteroid use, pituitary tumor). Cortrosyn is available in generic form.

What Are Side Effects of Cortrosyn?

Cortrosyn may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • itching,
  • red, swollen, blistered, or peeling skin with or without fever,
  • wheeze,
  • tightness in the chest or throat,
  • difficulty swallowing or talking,
  • unusual hoarseness,
  • headache,
  • dizziness,
  • fainting,
  • vision changes,
  • fast or slow heartbeats, and
  • swelling in the arms or legs

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Cortrosyn include:

  • minor irritation at the injection site
    • redness,
    • swelling,
    • rash,
  • rapid or slowed heart rate,
  • high blood pressure, and
  • swelling in limbs

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Cortrosyn

When given as an intravenous infusion, Cortrosyn in a 0.25 mg dose may be added to glucose or saline solutions and given at the rate of approximately 40 micrograms per hour over a 6-hour period.

What Drugs, Substances, or Supplements Interact with Cortrosyn?

Cortrosyn may interact with cortisone, estrogen, hydrocortisone, spironolactone, or diuretics. Tell your doctor all medications and supplements you use.

Cortrosyn During Pregnancy and Breastfeeding

During pregnancy, Cortrosyn should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Cortrosyn (cosyntropin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cortrosyn Professional Information

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Since CORTROSYN® (cosyntropin) for Injection is intended for diagnostic and not therapeutic use, adverse reactions other than a rare hypersensitivity reaction are not anticipated. A rare hypersensitivity reaction usually associated with a pre-existing allergic disease and/or a previous reaction to natural ACTH is possible. Symptoms may include slight whealing with splotchy erythema at the injection site. There have been rare reports of anaphylactic reaction. The following adverse reactions have been reported in patients after the administration of CORTROSYN® and the association has been neither confirmed nor refuted:

  • bradycardia
  • tachycardia
  • hypertension
  • peripheral edema
  • rash


Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.

Read the entire FDA prescribing information for Cortrosyn (Cosyntropin)

© Cortrosyn Patient Information is supplied by Cerner Multum, Inc. and Cortrosyn Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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