Medical Editor: John P. Cunha, DO, FACOEP
Corzide (nadolol and bendroflumethiazide) is a combination beta-blocker and diuretic used to treat high blood pressure (hypertension). Corzide is available in generic form. Common side effects of Corzide include:
- spinning sensation
- slow heartbeat
- upset stomach
- blurred vision
- ringing in your ears, and
- decreased sexual ability
Dosing of Corzide is individualized. The initial dose of Corzide may be 40 mg/5 mg tablet once daily. Corzide may interact with narcotics, barbiturates, amphotericin B, blood thinners, calcium supplements, colestipol, cholestyramine, diazoxide, digoxin, gout medications, insulin or oral diabetes medicines, lithium, MAO inhibitors, steroids, other heart or blood pressure medications, or NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use. During pregnancy, Corzide should be used only if prescribed. It may harm a fetus. This medication passes into breast milk. Nadolol may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Corzide (nadolol and bendroflumethiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- swelling, rapid weight gain, feeling short of breath, even with mild exertion;
- fast, slow, or uneven heartbeat;
- easy bruising or bleeding;
- numbness or tingly feeling in your hands or feet;
- feeling weak, drowsy, restless, or light-headed;
- nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
- increased urination, leg discomfort, muscle pain or weakness or limp feeling;
- urinating less than usual or not at all;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
- upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- diarrhea, constipation, upset stomach;
- dizziness, spinning sensation;
- blurred vision;
- depressed mood; or
- ringing in your ears.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Corzide (Nadolol and Bendroflumethiazide)
Most adverse effects have been mild and transient and have rarely required withdrawal of therapy.
Bradycardia with heart rates of less than 60 beats per minute occurs commonly, and heart rates below 40 beats per minute and/or symptomatic bradycardia were seen in about 2 of 100 patients. Symptoms of peripheral vascular insufficiency, usually of the Raynaud type, have occurred in approximately 2 of 100 patients. Cardiac failure, hypotension, and rhythm/conduction disturbances have each occurred in about 1 of 100 patients. Single instances of first degree and third degree heart block have been reported; intensification of AV block is a known effect of beta-blockers (see CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS).
Central Nervous System
Dizziness or fatigue has been reported in approximately 2 of 100 patients; paresthesias, sedation, and change in behavior have each been reported in approximately 6 of 1000 patients.
Each of the following has been reported in 1 to 5 of 1000 patients: rash; pruritus; headache; dry mouth, eyes, or skin; impotence or decreased libido; facial swelling; weight gain; slurred speech; cough; nasal stuffiness; sweating; tinnitus; blurred vision. Reversible alopecia has been reported infrequently.
The following adverse reactions have been reported in patients taking nadolol and/or other betaadrenergic blocking agents, but no causal relationship to nadolol has been established.
Central Nervous System
Reversible mental depression progressing to catatonia; visual disturbances; hallucinations; an acute reversible syndrome characterized by disorientation for time and place, shortterm memory loss, emotional lability with slightly clouded sensorium, and decreased performance on neuropsychometrics.
Fever combined with aching and sore throat; laryngospasm; respiratory distress.
Pemphigoid rash; hypertensive reaction in patients with pheochromocytoma; sleep disturbances; Peyronie's disease.
The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with nadolol.
Nausea, vomiting, cramping and anorexia are not uncommon; diarrhea, constipation, gastric irritation, abdominal bloating, jaundice (intrahepatic cholestatic jaundice), hepatitis, and sialadenitis occasionally occur; and pancreatitis has been reported.
Central Nervous System
Purpura, exfoliative dermatitis, pruritus, ecchymosis, urticaria, necrotizing angiitis (vasculitis, cutaneous vasculitis), respiratory distress including pneumonitis, fever, and anaphylactic reactions occasionally occur; photosensitivity and rash have been reported.
Orthostatic hypotension may occur and may be potentiated by coadministration with certain other drugs (e.g., alcohol, barbiturates, narcotics, other antihypertensive medications, etc.; see DRUG INTERACTIONS).
Muscle spasm, weakness, or restlessness is not uncommon; hyperglycemia, glycosuria, metabolic acidosis in diabetic patients, hyperuricemia, allergic glomerulonephritis, and transient blurred vision occasionally occur.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
Read the entire FDA prescribing information for Corzide (Nadolol and Bendroflumethiazide)
© Corzide Patient Information is supplied by Cerner Multum, Inc. and Corzide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.