Cosentyx vs. Humira

Reviewed on 11/5/2019

Are Cosentyx and Humira the Same Thing?

Cosentyx (secukinumab) for Injection and Humira (adalimumab) are used to treat moderate to severe plaque psoriasis.

Humira is also used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

Cosentyx and Humira are different types of monoclonal antibodies. Cosentyx is a monoclonal antibody to interleukin-17A and Humira is a tumor necrosis factor (TNF) blocker.

Side effects of Cosentyx and Humira that are similar include stuffy or runny nose.

Side effects of Cosentyx that are different from Humira include sore throat and nose, diarrhea, upper respiratory tract infection, sinus infection (sinusitis), oral herpes, hives, athlete's foot, tonsillitis, oral thrush, impetigo, inflammatory bowel disease, ear infection, eye infection or inflammation (conjunctivitis), increased liver transaminases, and low white blood cell count (neutropenia).

Side effects of Humira that are different from Cosentyx include injection site reactions (redness, itching, pain, bruising, swelling, or bleeding), headache, sinus pain, and stomach pain.

Both Cosentyx and Humira may interact with "live" vaccines.

Cosentyx may also interact with warfarin and cyclosporine.

Humira may also interact with abatacept, etanercept, anakinra, azathioprine, mercaptopurine, certolizumab, golimumab, infliximab, and rituximab.

What Are Possible Side Effects of Cosentyx?

Common side effects of Cosentyx include:

  • sore throat and nose,
  • diarrhea,
  • upper respiratory tract infection,
  • sinus infection (sinusisits),
  • stuffy or runny nose,
  • oral herpes,
  • hives,
  • athlete's foot,
  • tonsillitis,
  • oral thrush,
  • impetigo,
  • inflammatory bowel disease,
  • ear infection,
  • eye infection or inflammation (conjunctivitis),
  • increased liver transaminases, and
  • low white blood cell count (neutropenia).

What Are Possible Side Effects of Humira?

Common side effects of Humira include:

  • fast/irregular/pounding heartbeat,
  • stomach pain,
  • blood in the stools,
  • mental/mood changes,
  • severe headache,
  • easy bruising or bleeding,
  • dark urine,
  • yellowing eyes and skin,
  • leg pain or swelling,
  • numbness or tingling of the arms/hands/legs/feet,
  • unsteadiness,
  • unexplained muscle weakness,
  • difficulty with speaking/chewing/swallowing/facial movements,
  • vision changes,
  • extreme fatigue,
  • joint pain, or
  • butterfly-shaped rash on the nose and cheeks.

What Is Cosentyx?

Cosentyx (secukinumab) for Injection is a human interleukin-17A antagonist used to treat moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy.

What Is Humira?

Humira (adalimumab) is an injectable protein (antibody) used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow

What Drugs Interact With Cosentyx?

Cosentyx may interact with warfarin, cyclosporine, or "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Cosentyx. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Humira?

Humira may interact with azathioprine or mercaptopurine. Asacol may also interact with pentamidine, tacrolimus, amphotericin B, antibiotics, antiviral medicines, cancer medicine, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs).

Humira may also interact with abatacept, anakinra, infliximab, etanercept, certolizumab pegol, golimumab, or rituximab.

How Should Cosentyx Be Taken?

The recommended dose of Cosentyx is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks. Each 300 mg dose is given as 2 subcutaneous injections of 150 mg.

How Should Humira Be Taken?

Humira is given by an injection under the skin. Your doctor will tell you how often to take an injection of Humira. This is based on your condition to be treated. Do not inject Humira more often than you were prescribed.

Do not try to inject Humira yourself until you have been shown the right way to give the injections. If your doctor decides that you or a caregiver may be able to give your injections of Humira at home, you should receive training on the right way to prepare and inject Humira.

Do not miss any doses of Humira unless your doctor says it is okay. If you forget to take Humira, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. This will put you back on schedule.

In case you are not sure when to inject Humira, call your doctor or pharmacist.

If you take more Humira than you were told to take, call your doctor.

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
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References
Novartis. Cosentyx Product Monograph.

http://www.cosentyx.com

AbbVie. Humira Product Information.

https://www.pfizer.com/products/product-detail/azulfidine

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