Cosentyx vs. Stelara

Reviewed on 11/5/2019

Are Cosentyx and Stelara the Same Thing?

Cosentyx (secukinumab) for Injection and Stelara (ustekinumab) Injection are human monoclonal antibodies used to treat moderate to severe plaque psoriasis.

Cosentyx and Stelara are different types of monoclonal antibodies. Cosentyx is a human monoclonal antibody to interleukin-17A and Stelara is a human monoclonal antibody to interleukin (IL)-12 and IL-23.

Side effects of Cosentyx and Stelara that are similar include cold symptoms (stuffy nose, sneezing, sore throat) and diarrhea.

Side effects of Cosentyx that are different from Stelara include upper respiratory tract infection, sinus infection (sinusitis), oral herpes, hives, athlete's foot, tonsillitis, oral thrush, impetigo, inflammatory bowel disease, ear infection, eye infection or

inflammation (conjunctivitis), increased liver transaminases, and low white blood cell count (neutropenia).

Side effects of Stelara that are different from Cosentyx include injection site reactions (bruising, itching, pain, redness, swelling, and hardening of the skin), headache, tired feeling, and skin rash or itching.

Both Cosentyx and Stelara may interact with "live" vaccines.

Cosentyx may also interact with warfarin and cyclosporine.

What Are Possible Side Effects of Cosentyx?

Common side effects of Cosentyx include:

  • sore throat and nose,
  • diarrhea,
  • upper respiratory tract infection,
  • sinus infection (sinusisits),
  • stuffy or runny nose,
  • oral herpes,
  • hives,
  • athlete's foot,
  • tonsillitis,
  • oral thrush,
  • impetigo,
  • inflammatory bowel disease,
  • ear infection,
  • eye infection or inflammation (conjunctivitis),
  • increased liver transaminases, and
  • low white blood cell count (neutropenia).

What Are Possible Side Effects of Stelara?

Common side effects of Stelara include:

  • injection site reactions (bruising, itching, pain, redness, swelling, and hardening of the skin),
  • cold symptoms (stuffy nose, sneezing, sore throat),
  • headache,
  • tired feeling,
  • diarrhea, or
  • skin rash or itching.

Stelara can affect your immune system and can lower your body's ability to fight an infection. Tell your doctor if you develop signs of an infection, such as worsening redness/swelling/tenderness at the injection site after 2 days, fever or chills, cold or flu symptoms, severe stomach pain, or persistent nausea or vomiting.

What Is Cosentyx?

Cosentyx (secukinumab) for Injection is a human interleukin-17A antagonist used to treat moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy.

What Is Stelara?

Stelara (ustekinumab) Injection is a monoclonal antibody used to treat plaque psoriasis.

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow

What Drugs Interact With Cosentyx?

p>Cosentyx may interact with warfarin, cyclosporine, or "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Cosentyx. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Stelara?

Live vaccines such as the polio and flu vaccine may interact with Stelara. Tell your doctor all medications you use, all recent vaccines you have received, and all infections you have had. Stelara may weaken your body's ability to fight infections. If you are pregnant only take Stelara if clearly needed. Exercise caution if you are taking Stelara and are breastfeeding.

How Should Cosentyx Be Taken?

The recommended dose of Cosentyx is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks. Each 300 mg dose is given as 2 subcutaneous injections of 150 mg.

How Should Stelara Be Taken?

The recommended dosage of Stelara is either 45 mg or 90 mg given on day one, then 4 weeks later, and every 12 weeks thereafter.

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
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References
Novartis. Cosentyx Product Monograph.

http://www.cosentyx.com

Janssen Biotech. Stelara Product Information.

https://www.stelarainfo.com

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