Reviewed on 9/14/2021

What Is Dexpanthenol Used For and How Does it Work?

Dexpanthenol is an over-the-counter (OTC) topical skin cream used to treat dermatoses and eczema.

Dexpanthenol is available under the following different brand names: Panthoderm.

Dosages of Dexpanthenol

Topical Cream

  • 2%

Dosage Considerations – Should be Given as Follows:

Dermatoses and Eczema

  • Apply topically to affected area(s) once daily or every 12 hours


Eczema (also atopic eczema or atopic dermatitis) is a general medical term for many types of skin inflammation. See Answer

What Are Side Effects Associated with Using Dexpanthenol?

Side effects of Dexpanthenol include:

  • Itching
  • Tingling
  • Irritation
  • Hives
  • Allergic reactions

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Dexpanthenol?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Dexpanthenol has no listed severe interactions with other drugs.
  • Dexpanthenol has no listed serious interactions with other drugs.
  • Dexpanthenol has no listed moderate interactions with other drugs.
  • Dexpanthenol has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Dexpanthenol?


This medication contains dexpanthenol. Do not take Panthoderm if you are allergic to dexpanthenol or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Hypersensitivity

Effects of Drug Abuse

  • No information available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Dexpanthenol?"

Long-Term Effects

  • Continuous use for 3-6 months may cause dizziness, dry mouth, nose bleeds, and upset stomach
  • See "What Are Side Effects Associated with Using Dexpanthenol?"


  • External use only
  • Avoid eyes

Pregnancy and Lactation

Use dexpanthenol with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done. Dexpanthenol is possibly excreted in milk; use with caution while breastfeeding. Pregnant or breastfeeding patients should seek the advice of their health professional before using over-the-counter (OTC) drugs.


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