Cozaar vs. Lisinopril

Are Cozaar and Lisinopril the Same Thing?

Cozaar (losartan) and lisinopril are used to treat hypertension.

Lisinopril is also used to treat congestive heart failure and to improve survival after a heart attack.

Cozaar and lisinopril belong to different drug classes. Cozaar is an angiotensin receptor blocker (ARB) and lisinopril is an angiotensin-converting enzyme inhibitor(ACE).

Brand names for lisinopril include Zestril, Prinivil, and Qbrelis.

What Are Possible Side Effects of Cozaar?

Common side effects of Cozaar include:

Tell your doctor if you experience serious side effects of Cozaar including pain or burning when you urinate; pale skin, lightheadedness, shortness of breath, rapid heart rate, trouble concentrating; wheezing, chest pain; drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting; swelling, weight gain, urinating less than usual or not at all; or high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling).

What Are Possible Side Effects of Lisinopril?

Common side effects of Lisinopril include:

  • cough,
  • dizziness,
  • drowsiness,
  • headache,
  • depression,
  • nausea,
  • vomiting,
  • diarrhea,
  • upset stomach, and
  • mild skin itching or rash.

Tell your doctor if you have unlikely but serious side effects of Lisinopril including:

  • fainting,
  • symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat, weak pulse, tingly feeling),
  • signs of infection (such as fever, chills, persistent sore throat, body aches, flu symptoms),
  • changes in the amount of urine,
  • swelling,
  • rapid weight gain,
  • tired feeling,
  • pounding or uneven heartbeats,
  • psoriasis (raised, silvery flaking of the skin), or
  • chest pain.

What Is Cozaar?

Cozaar (losartan) is an oral angiotensin receptor blocker (ARB) prescribed for the treatment of hypertension.

What Is Lisinopril?

is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension), congestive heart failure, and to improve survival after a heart attack.


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What Drugs Interact With Cozaar?

Cozaar may interact with diuretics (water pills), other blood pressure medications, lithium, celecoxib, or aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).

What Drugs Interact With Lisinopril?

Lisinopril may interact with diuretics (water pills), other blood pressure medications, lithium, or aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Lisinopril may also interact with gold injections, potassium supplements, salt substitutes that contain potassium, and insulin or oral diabetes medications.

How Should Cozaar Be Taken?

Dosing preparations of Cozaar are 25, 50, and 100 mg tablets. Drug interactions with Cozaar may occur with inhibitors of cytochrome P450, potassium- sparing diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Cozaar should not be used during pregnancy, and it is not known whether it is excreted in breast milk.

How Should Lisinopril Be Taken?

The recommended initial dose of Lisinopril is 10 mg once a day. Lisinopril is taken orally in tablet form.


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Medical Editor: John P. Cunha, DO, FACOEP


RxList. Cozaar Medication Guide.

RxList. Zestril Product Monograph.

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