Creon 20 Side Effects Center

Last updated on RxList: 9/21/2022
Creon 20 Side Effects Center

What Is Creon 20?

Creon 20 Minimicrospheres (pancrelipase) Delayed-release Capsules is a combination of three enzymes (proteins): lipase, protease, and amylase and is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts. Creon 20 Minimicrospheres may also be used following surgical removal of the pancreas.

What Are Side Effects of Creon 20?

Creon 20 may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • joint pain or swelling,
  • severe or unusual stomach pain,
  • vomiting,
  • bloating,
  • diarrhea, and
  • constipation

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Creon 20 Minimicrospheres include:

  • diarrhea
  • constipation
  • abdominal pain or cramps
  • dizziness
  • nausea
  • vomiting
  • stomach pain or upset
  • bloating
  • gas
  • greasy stools
  • rectal irritation
  • headache
  • dizziness
  • cough, or
  • weight loss

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Creon 20

The usual initial starting dosage for adults and children over age 6 is one Creon 20 Capsules per meal or snack. The pediatric dose is determined by a physician.

What Drugs, Substances, or Supplements Interact with Creon 20?

Creon 20 may interact with other drugs. Tell your doctor all medications and supplements you use.

Creon 20 During Pregnancy and Breastfeeding

During pregnancy, Creon 20 should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Creon 20 Minimicrospheres (pancrelipase) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Creon 20 Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • joint pain or swelling; or
  • symptoms of a rare but serious bowel disorder--severe or unusual stomach pain, vomiting, bloating, diarrhea, constipation.

Tell your doctor if your child is not growing at a normal rate while using pancrelipase.

Common side effects may include:

  • stomach pain, gas, vomiting;
  • diarrhea, frequent or abnormal bowel movements;
  • rectal itching;
  • headache, dizziness;
  • runny or stuffy nose, cough, sore throat; or
  • changes in your blood sugar.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Creon 20 Professional Information


The most frequently reported adverse reactions to pancreatic enzyme-containing products are gastrointestinal in nature which may include nausea, vomiting, bloating, cramping, constipation or diarrhea. Less frequently, allergic-type reactions have also been observed. Very high doses of pancreatin have been associated with hyperuricosuria and hyperuricemia.

Read the entire FDA prescribing information for Creon 20 (Pancrelipase Delayed-Released Capsules)

© Creon 20 Patient Information is supplied by Cerner Multum, Inc. and Creon 20 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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