Creon 5

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 2/2/2022
Creon 5 Side Effects Center

What Is Creon 5?

Creon 5 Minimicrospheres (pancrelipase) is a combination of three enzymes (proteins): lipase, protease, and amylase used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts. Creon 5 Minimicrospheres may also be used following surgical removal of the pancreas.

What Are Side Effects of Creon 5?

Common side effects of Creon 5 Minimicrospheres include:

  • diarrhea
  • constipation
  • abdominal pain/cramps
  • dizziness
  • nausea
  • vomiting
  • stomach upset
  • bloating
  • gas
  • greasy stools
  • rectal irritation
  • headache
  • cough, or
  • weight loss

Dosage for Creon 5

The usual initial starting dosage is two to four Creon 5 delayed-release capsules per meal or snack.

What Drugs, Substances, or Supplements Interact with Creon 5?

Creon 5 may interact with other drugs. Tell your doctor all medications and supplements you use.

Creon 5 During Pregnancy and Breastfeeding

During pregnancy, Creon 5 should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Creon 5 Minimicrospheres (pancrelipase) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Creon 5 Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • joint pain or swelling; or
  • symptoms of a rare but serious bowel disorder--severe or unusual stomach pain, vomiting, bloating, diarrhea, constipation.

Tell your doctor if your child is not growing at a normal rate while using pancrelipase.

Common side effects may include:

  • stomach pain, gas, vomiting;
  • diarrhea, frequent or abnormal bowel movements;
  • rectal itching;
  • headache, dizziness;
  • runny or stuffy nose, cough, sore throat; or
  • changes in your blood sugar.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Creon 5 (Pancrelipase Delayed-Release Minimicrospheres)


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Creon 5 Professional Information


The most frequently reported adverse reactions to pancreatic enzyme-containing products are gastrointestinal in nature which may include nausea, vomiting, bloating, cramping, constipation or diarrhea. Less frequently, allergic-type reactions have also been observed. Very high doses of pancreatin have been associated with hyperuricosuria and hyperuricemia.

Read the entire FDA prescribing information for Creon 5 (Pancrelipase Delayed-Release Minimicrospheres)

© Creon 5 Patient Information is supplied by Cerner Multum, Inc. and Creon 5 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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