Last updated on RxList: 7/19/2021
Cryselle Side Effects Center

What Is Cryselle?

Cryselle (norgestrel and ethinyl estradiol tablets) is an oral contraceptive indicated for the prevention of pregnancy in women. Cryselle is available in generic form.

What Are Side Effects of Cryselle?

Common side effects of Cryselle include:

  • nausea,
  • vomiting,
  • abdominal cramps,
  • bloating,
  • breakthrough bleeding,
  • spotting,
  • changes in menstrual flow,
  • missed menstrual periods,
  • temporary infertility after discontinuation of treatment,
  • fluid retention (edema),
  • spotty darkening of skin which may persist,
  • breast tenderness or enlargement,
  • nipple secretion,
  • change in weight,
  • change in vaginal discharge,
  • reduction in lactation when given immediately postpartum,
  • migraine,
  • allergic rash,
  • depression,
  • vaginal yeast infection, and
  • intolerance to contact lenses.

Cigarette smoking increases the risk of serious cardiovascular side effects from use of oral contraceptives such as Cryselle. Women who use oral contraceptives including Cryselle are strongly advised not to smoke.

Dosage for Cryselle

To achieve maximum contraceptive effectiveness, Cryselle must be taken exactly as directed and at intervals not exceeding 24 hours. The dosage of Cryselle is one white tablet daily for 21 consecutive days, followed by one light-green inert tablet daily for 7 consecutive days, according to prescribed schedule.

What Drugs, Substances, or Supplements Interact with Cryselle?

Cryselle may interact with rifampin, barbiturates, phenylbutazone, phenytoin sodium, griseofulvin, ampicillin, tetracycline antibiotics, and HCV drug combinations containing ombitasvir/paritaprevir/ritonavir (with or without dasabuvir). Tell your doctor all medications and supplements you use.

Cryselle During Pregnancy and Breastfeeding

Cryselle is not recommended for use during pregnancy. Small amounts of Cryselle pass into breast milk and may cause adverse reactions in nursing infants. Breastfeeding while using Cryselle is not recommended.

Additional Information

Our Cryselle (norgestrel and ethinyl estradiol tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Which of the following are methods for contraception? See Answer
Cryselle Professional Information


An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (see WARNINGS section):

There is evidence of an association between the following conditions and the use of oral contraceptives, although additional confirmatory studies are needed:

  • Mesenteric thrombosis
  • Retinal thrombosis

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug related:

  • Nausea
  • Vomiting
  • Gastrointestinal symptoms (such as abdominal cramps and bloating)
  • Breakthrough bleeding
  • Spotting
  • Change in menstrual flow
  • Amenorrhea
  • Temporary infertility after discontinuation of treatment
  • Edema
  • Melasma which may persist
  • Breast changes: tenderness, enlargement, secretion
  • Change in weight (increase or decrease)
  • Change in cervical erosion and secretion
  • Diminution in lactation when given immediately postpartum
  • Cholestatic jaundice
  • Migraine
  • Rash (allergic)
  • Mental depression
  • Reduced tolerance to carbohydrates
  • Vaginal candidiasis
  • Change in corneal curvature (steepening)
  • Intolerance to contact lenses

The following adverse reactions have been reported in users of oral contraceptives, and the association has been neither confirmed nor refuted:

Read the entire FDA prescribing information for Cryselle (Norgestrel and Ethinyl Estradiol)


Choosing Your Birth Control Method See Slideshow

© Cryselle Patient Information is supplied by Cerner Multum, Inc. and Cryselle Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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