Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 1/18/2022
Cyclocort Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Cyclocort?

Cyclocort (amcinonide) is a high potency topical corticosteroid indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses for a maximum duration of 5 days on the face, axillae, scrotum and scalp and a maximum of 3 weeks on the body.

What Are Side Effects of Cyclocort?

Common side effects of Cyclocort include:

  • itchy skin, and
  • skin burning or pain at the application site.

Use of Cyclocort for a long period of time, over a large body surface, or use under an airtight dressing, may cause the following rare side effects including:

  • weight gain,
  • moon face/rounding of the face,
  • obesity,
  • skin thinning,
  • stretch marks,
  • skin wrinkling,
  • skin dryness,
  • the appearance of blood vessels under the surface of your skin,
  • skin discoloration,
  • skin infection,
  • increased body hair,
  • hair loss,
  • allergic reaction,
  • irritation,
  • inflammation of hair follicles,
  • worsening of condition,
  • redness,
  • rash or hives,
  • dermatitis (a type of eczema),
  • upper abdominal pain,
  • prickly heat rash, or
  • acne.

Dosage for Cyclocort

Apply a thin layer dose of Cyclocort to affected area once or twice daily and gently rub in. Allow adequate time for absorption after each application before applying an emollient.

What Drugs, Substances, or Supplements Interact with Cyclocort?

Cyclocort may interact with ritonavir and itraconazole, and it may impair the effectiveness of latex products (e.g. condoms, diaphragms). Tell your doctor all medications and supplements you use.

Cyclocort During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Cyclocort; it is unknown if it will harm a fetus. The minimum quantity Cyclocort should be used for the minimum duration in pregnant patients. It is unknown if Cyclocort passes into breast milk. Systemically administered corticosteroids pass into breast milk. Nursing mothers must not apply Cyclocort to the breast area in order to prevent direct contact of the nursing infant with the active ingredient. Consult your doctor before breastfeeding.

Additional Information

Our Cyclocort (amcinonide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Cyclocort Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, headaches, pain behind the eyes, tiredness, mood changes, menstrual changes, sexual changes.

Steroid medicine can affect growth in children. Tell your doctor if your child is not growing or gaining weight at a normal rate while using amcinonide topical.

Common side effects may include:

  • burning, itching, irritation, or dryness of treated skin;
  • redness or crusting around your hair follicles;
  • acne, increased hair growth;
  • stretch marks, thinning skin; or
  • white or "pruned" appearance of the skin (caused by covering treated skin with a tight bandage or other covering).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cyclocort (amcinonide)


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Cyclocort Professional Information


Post-Market Adverse Drug Reactions

The following adverse reactions are reported when topical corticosteroids are used as recommended. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish causal relationship to drug exposure.

Endocrine Disorders

Hypothalamic-pituitary adrenal (HPA) axis suppression, cushingoid features (e.g. moon face, central obesity), delayed weight gain/growth retardation in children, osteoporosis, hyperglycemia/glucosuria, hypertension, increased weight/obesity, decreased endogenous cortisol levels, steroid withdrawal syndrome

Eye Disorders

glaucoma, cataract subcapsular

Gastrointestinal Disorders

upper abdominal pain

General Disorders And Administration Site Conditions

Application site irritation/pain.

Immune System Disorders

local hypersensitivity (see Skin And Subcutaneous Tissue Disorders)

Infections And Infestations

secondary infection


Decreased glucose tolerance has also been reported

Skin And Subcutaneous Tissue Disorders

skin striae, skin atrophy, telangiectasia, purpura-like bleeding, acne, dermatitis, hypertrichosis, skin depigmentation, erythema, burning sensation, pruritus, eczema, dryness, itching, local irritation, atrophy of the subcutaneous tissues, pustules, miliaria, folliculitis, pyoderma, allergic contact dermatitis, acneiform eruptions, perioral dermatitis, rash, urticaria, pustular psoriasis, skin wrinkling, alopecia, trichorrhexis, skin infection.

Vascular Disorders


Read the entire FDA prescribing information for Cyclocort (amcinonide)

© Cyclocort Patient Information is supplied by Cerner Multum, Inc. and Cyclocort Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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