Cyclogyl Side Effects Center

Last updated on RxList: 2/24/2021
Cyclogyl Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Cyclogyl?

Cyclogyl (cyclopentolate hydrochloride ophthalmic solution) is an anticholinergic used to produce dilated pupils (mydriasis) and paralysis of the iris muscle in the eye (cycloplegia) for diagnostic procedures.

What Are Side Effects of Cyclogyl?

Common side effects of Cyclogyl include:

  • increased eye pressure,
  • burning,
  • eye sensitivity to light,
  • blurred vision,
  • irritation,
  • eye redness,
  • conjunctivitis,
  • eyelid swelling,
  • eye inflammation, and
  • eye disorders such as punctate keratitis and synechiae

Dosage for Cyclogyl

The adult dose of Cyclogyl is one or two drops of 0.5%, 1% or 2% solution instilled in the eye, which may be repeated in five to ten minutes if necessary. Complete recovery usually occurs in 24 hours.

What Drugs, Substances, or Supplements Interact with Cyclogyl?

Cyclogyl may interact with carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors. Tell your doctor all medications and supplements you use.

Cyclogyl During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Cyclogyl; it is unknown if it would harm a fetus. It is unknown if Cyclogyl passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Cyclogyl (cyclopentolate hydrochloride ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Cyclogyl Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • severe burning or redness of your eyes;
  • drowsiness;
  • constipation, little or no urinating;
  • dry mouth or nose, decreased sweating;
  • fast heartbeats; or
  • fever, skin rash, flushing (warmth, redness, or tingly feeling).

Infants and young children may be more likely to have side effects from cyclopentolate ophthalmic. For at least 30 minutes after the child has been treated with this medicine, watch for the following side effects:

  • loss of coordination;
  • unusual changes in behavior;
  • feeling restless or excited;
  • confusion, speech problems; or
  • feeding problems, stomach bloating.

Common side effects may include:

  • blurred vision;
  • mild eye irritation or redness;
  • puffy eyelids; or
  • the eyes being more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Cyclogyl Professional Information



Increased intraocular pressure, burning, photophobia, blurred vision, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctuate keratitis, synechiae have been reported.


Use of cyclopentolate has been associated with psychotic reactions and behavioral disturbances, usually in children, especially with 2% concentration. These disturbances include ataxia, incoherent speech, restlessness, hallucinations, hyperactivity, seizures, disorientation as to time and place, and failure to recognize people. This drug produces reactions similar to those of other anticholinergic drugs, but the central nervous system manifestations as noted above are more common. Other toxic manifestations of anticholinergic drugs are skin rash, abdominal distention in infants, unusual drowsiness, tachycardia, hyperpyrexia, vasodilation, urinary retention, diminished gastrointestinal motility and decreased secretion in salivary and sweat glands, pharynx, bronchi and nasal passages. Severe manifestations of toxicity include coma, medullary paralysis and death.

Read the entire FDA prescribing information for Cyclogyl (Cyclopentolate Hydrochloride Ophthalmic Solution)

© Cyclogyl Patient Information is supplied by Cerner Multum, Inc. and Cyclogyl Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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