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Last reviewed on RxList: 7/28/2020
Cylert Side Effects Center

What Is Cylert?

Cylert (pemoline) is a central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD). The brand name Cylert is no longer available in the U.S. Generic versions may be available.

What Are Side Effects of Cylert?

Common side effects of Cylert (pemoline) include:

  • insomnia (difficulty sleeping),
  • nervousness,
  • headache,
  • drowsiness,
  • mild depression,
  • nausea,
  • abdominal discomfort,
  • diarrhea,
  • decreased appetite (anorexia),
  • weight loss,
  • rapid heart rate, and
  • rash

In rare cases, Cylert (pemoline) has caused severe liver damage resulting in death or liver transplant. Notify your doctor if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, clay-colored stools, or dark urine. These symptoms may be early signs of liver damage.

Dosage for Cylert

The recommended starting dose of pemoline is 37.5 mg/day, taken as a single dose once each morning. The effective daily dose for most patients ranges from 56.25 to 75 mg. The maximum recommended daily dose of pemoline is 112.5 mg.

What Drugs, Substances, or Supplements Interact with Cylert?

There may be an increased risk of seizures when pemoline is taken with antiepileptic medications. Other drugs may interact with pemoline. Tell your doctor all prescription or over-the-counter medicines you use.

Cylert During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant before taking pemoline. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Additional Information

Our Cylert (pemoline) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


ADHD Symptoms in Children See Slideshow
Cylert Professional Information


The following are adverse reactions in decreasing order of severity within each category associated with CYLERT (pemoline) :

Hepatic: There have been reports of hepatic dysfunction, ranging from asymptomatic reversible increases in liver enzymes to hepatitis, jaundice and life- threatening hepatic failure, in patients taking CYLERT (see PRECAUTIONS and WARNINGS).

Hematopoietic: There have been isolated reports of aplastic anemia.

Central Nervous System: The following CNS effects have been reported with the use of CYLERT (pemoline) : convulsive seizures: literature reports indicate that CYLERT (pemoline) may precipitate attacks of Gilles de la Tourette syndrome; hallucinations; dyskinetic movements of the tongue, lips, face and extremities: abnorrnal oculomotor function including nystagmus and oculogyric crisis; mild depression; dizziness; increased irritability; headache; and drowsiness.

Insomnia is the most frequently reported side effect of CYLERT (pemoline) , it usually occurs early in therapy prior to an optimum therapeutic response. In the majority of cases it is transient in nature or responds to a reduction in dosage.

Gastrointestinal: Anorexia and weight loss may occur during the first weeks of therapy. In the majority of cases it is transient in nature; weight gain usually resumes within three to six months.

Nausea and stomach ache have also been reported.

Genitourinary: A case of elevated acid phosphatase in association with prostatic enlargement has been reported in a 63 year old male who was treated with CYLERT (pemoline) for sleepiness. The acid phosphatase normalized with discontinuation of CYLERT (pemoline) and was again elevated with rechallenge.

Miscellaneous: Suppression of growth has been reported with the long- term use of stimulants in children. (See WARNINGS.) Skin rash has been reported with CYLERT (pemoline) .

Mild adverse reactions appearing early during the course of treatment with CYLERT (pemoline) often remit with continuing therapy. If adverse reactions are of a significant or protracted nature, dosage should be reduced or the drug discontinued.


Controlled Substance: CYLERT (pemoline) is subject to control under DEA schedule IV.

Abuse: CYLERT (pemoline) failed to demonstrate a potential for self- administration in primates. However, the pharmacologic similarity of pemoline to other psychostimulants with known dependence liability suggests that psychological and/ or physical dependence might also occur with CYLERT (pemoline) . There have been isolated reports of transient psychotic symptoms occurring in adults following the long- term misuse of excessive oral doses of pemoline. CYLERT (pemoline) should be given with caution to emotionally unstable patients who may increase the dosage on their own initiative.

Read the entire FDA prescribing information for Cylert (Pemoline)


The abbreviated term ADHD denotes the condition commonly known as: See Answer
Related Resources for Cylert

© Cylert Patient Information is supplied by Cerner Multum, Inc. and Cylert Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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