Cymbalta vs. Lyrica

Are Cymbalta and Lyrica the Same Thing?

Cymbalta (duloxetine) and Lyrica (pregabalin) are used to treat pain associated with diabetic peripheral neuropathy or fibromyalgia.

Cymbalta is also used to treat depression and anxiety disorder.

Lyrica is also used to treat partial onset seizures in adults.

Cymbalta and Lyrica belong to different drug classes. Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant and Lyrica is an anti-epileptic drug (anticonvulsant).

What Are Possible Side Effects of Cymbalta?

Common side effects of Cymbalta include:

What Are Possible Side Effects of Lyrica?

Common side effects of Lyrica include:

What Is Cymbalta?

Cymbalta is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). Cymbalta belongs to a class of medicines known as SNRIs (or serotonin-norepinephrine reuptake inhibitors).

Cymbalta is also used to treat or manage:

What Is Lyrica?

Lyrica (pregabalin) is an anti-epileptic drug (anticonvulsant) used for neuropathic (nerve) pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and for treating partial onset seizures in adults, and fibromyalgia.

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What Drugs Interact With Cymbalta?

Do Not take Cymbalta if you:

  • take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid or intravenous methylene blue.
  • Do not take an MAOI within 5 days of stopping Cymbalta unless directed to do so by your healthcare provider.
  • Do not start Cymbalta if you stopped taking an MAOI in the last 14 days unless directed to do so by your healthcare provider.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Cymbalta and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Especially tell your healthcare provider if you take:

Ask your healthcare provider for a list of these medicines if you are not sure.

Do not take Cymbalta with any other medicine that contain duloxetine.

What Drugs Interact With Lyrica?

Lyrica may also interact with alcohol, other medicines that can make you sleepy (sold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for anxiety), or rosiglitazone.

How Should Cymbalta Be Taken?

Take Cymbalta exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of Cymbalta until it is the right dose for you.

Swallow Cymbalta whole. Do not chew or crush Cymbalta.

Do not open the capsule and sprinkle on food or mix with liquids. Opening the capsule may affect how well Cymbalta works.

Cymbalta may be taken with or without food.

If you miss a dose of Cymbalta, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Cymbalta at the same time.

If you take too much Cymbalta, call your healthcare provider or poison control center at 1-800-222-1222 right away, or get emergency treatment.

How Should Lyrica Be Taken?

The recommended dose of Lyrica is 75-600 mg daily. Alcohol and drugs that cause sedation may increase the sedative effects of Lyrica. There are no adequate studies of Lyrica in pregnant women. If you become pregnant, your name may be listed on a pregnancy registry to track the outcome of the pregnancy and to evaluate any effects of Lyrica on the baby. It is unknown if Lyrica passes into breast milk or if it could harm a nursing baby. Breastfeeding while using Lyrica is not recommended.

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References

Lilly. Cymbalta Medication Guide.
https://pi.lilly.com/us/cymbalta-pi.pdf
Pfizer. Lyrica Prescribing Information.
https://www.lyrica.com

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