Cymbalta vs. Wellbutrin

Are Cymbalta and Wellbutrin the Same Thing?

Cymbalta (duloxetine) and Wellbutrin (bupropion) are antidepressants used for treating depression.

Cymbalta is also used to treat anxiety disorder, and pain associated with diabetic peripheral neuropathy or fibromyalgia. Wellbutrin is also used to treat seasonal affective disorder.

What Are Possible Side Effects of Cymbalta?

Common side effects of Cymbalta include:

What Are Possible Side Effects of Wellbutrin?

Common side effects of Wellbutrin include:

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow

What is Cymbalta?

Cymbalta is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). Cymbalta belongs to a class of medicines known as SNRIs (or serotonin-norepinephrine reuptake inhibitors).

Cymbalta is also used to treat or manage:

What is Wellbutrin?

Wellbutrin is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder.

What Drugs Interact With Cymbalta?

Do Not take Cymbalta if you:

  • take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid or intravenous methylene blue.
  • Do not take an MAOI within 5 days of stopping Cymbalta unless directed to do so by your healthcare provider.
  • Do not start Cymbalta if you stopped taking an MAOI in the last 14 days unless directed to do so by your healthcare provider.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Cymbalta and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Especially tell your healthcare provider if you take:

Ask your healthcare provider for a list of these medicines if you are not sure.

Do not take Cymbalta with any other medicine that contain duloxetine.

What Drugs Interact With Wellbutrin?

Do not take Wellbutrin if you:

  • have or had a seizure disorder or epilepsy.
  • are taking Zyban (used to help people stop smoking) or any other medicines that contain bupropion hydrochloride, such as Wellbutrin SR Sustained-Release Tablets or Wellbutrin XL Extended-Release Tablets. Bupropion is the same ingredient that is in Wellbutrin.
  • drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines and you stop using them all of a sudden.
  • have taken within the last 14 days medicine for depression called a monoamine oxidase inhibitor (MAOI), such as Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), or Marplan (isocarboxazid).
  • have or had an eating disorder such as anorexia nervosa or bulimia.
  • are allergic to the active ingredient in Wellbutrin, bupropion, or to any of the inactive ingredients. See the end of this leaflet for a complete list of ingredients in Wellbutrin.

QUESTION

Depression is a(n) __________ . See Answer

How Should Cymbalta Be Taken?

Take Cymbalta exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of Cymbalta until it is the right dose for you.

Swallow Cymbalta whole. Do not chew or crush Cymbalta.

Do not open the capsule and sprinkle on food or mix with liquids. Opening the capsule may affect how well Cymbalta works.

Cymbalta may be taken with or without food.

If you miss a dose of Cymbalta, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Cymbalta at the same time.

If you take too much Cymbalta, call your healthcare provider or poison control center at 1-800-222-1222 right away, or get emergency treatment.

When switching from another antidepressant to Cymbalta your healthcare provider

How Should Wellbutrin Be Taken?

Take Wellbutrin exactly as prescribed by your doctor.

  • Take Wellbutrin at the same time each day.
  • Take your doses of Wellbutrin at least 6 hours apart.
  • You may take Wellbutrin with or without food.
  • If you miss a dose, do not take an extra tablet to make up for the dose you forgot. Wait and take your next tablet at the regular time. This is very important. Too much Wellbutrin can increase your chance of having a seizure.
  • If you take too much Wellbutrin, or overdose, call your local emergency room or poison control center right away.
  • Do not take any other medicines while using Wellbutrin unless your doctor has told you it is okay.
  • It may take several weeks for you to feel that Wellbutrin is working. Once you feel better, it is important to keep taking Wellbutrin exactly as directed by your doctor. Call your doctor if you do not feel Wellbutrin is working for you.
  • Do not change your dose or stop taking Wellbutrin without talking with your doctor first.
Disclaimer

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Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

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You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

Cymbalta Drug Information.
http://pi.lilly.com/us/Cymbalta-Medguide.pdf
FDA. Wellbutrin Drug Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018644s041MedGuide.pdf

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