Cytogam

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 12/13/2021
Cytogam Side Effects Center

What Is Cytogam?

Cytogam [Cytomegalovirus Immune Globulin Intravenous (Human)] is a sterilized solution obtained from pooled human blood that contains the immunoglobulins (or antibodies) to protect against infection from cytomegalovirus and is used to help prevent infection by cytomegalovirus in people who receive an organ transplant. Cytogam may be available in generic form.

What Are Side Effects of Cytogam?

Common side effects of Cytogam include:

Dosage for Cytogam

The maximum recommended total dosage of Cytogam per infusion is 150 mg Ig/kg. Dosage schedule depends on the organ being transplanted.

What Drugs, Substances, or Supplements Interact with Cytogam?

Cytogam may interact with “live” vaccines (e.g., measles, mumps, and rubella or MMR) during and for approximately three months following treatment with CMV IG. Tell your doctor all medications and supplements you use and all vaccines you have recently received.

Cytogam During Pregnancy or Breastfeeding

During pregnancy, Cytogam should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Cytogam [Cytomegalovirus Immune Globulin Intravenous (Human)] Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

The only purpose of the kidneys is to filter blood. See Answer
Cytogam Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; dizziness, feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • blue lips, pale or blue colored appearance in your fingers or toes;
  • a red blood cell disorder--pale or yellowed skin, dark colored urine, confusion or weakness;
  • signs of a kidney problem--swelling, rapid weight gain, and little or no urinating;
  • lung problems--chest pain, severe shortness of breath, wheezing, cough with foamy mucus, fast or uneven heart rate; or
  • signs of new infection--high fever, flu symptoms, mouth sores, severe headache, neck stiffness, increased sensitivity to light, nausea and vomiting; or
  • signs of a blood clot--sudden numbness or weakness, slurred speech, problems with vision or balance; sudden cough, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs.

Common side effects may include:

  • chills;
  • mild nausea, vomiting;
  • joint pain;
  • back pain, muscle cramps; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cytogam (Cytomegalovirus Immune Globulin Intravenous Human)

SLIDESHOW

Kidney Stones: Symptoms, Causes, and Treatment See Slideshow
Cytogam Professional Information

SIDE EFFECTS

Minor reactions such as flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, and wheezing were the most frequent adverse reactions observed during the clinical trials of CYTOGAM, Cytomegalovirus Immune Globulin Intravenous (Human). The incidence of these reactions during the clinical trials was less than 6.0% of all infusions and such reactions were most often related to infusion rates. A decrease in blood pressure was observed in 1 of 1039 infusions in clinical trials of CYTOGAM. If a patient develops a minor side effect, slow the rate immediately or temporarily interrupt the infusion.

Increases in serum creatinine and blood urea nitrogen (BUN) have been observed as soon as one to two days following IGIV infusion. Progression to oliguria or anuria requiring dialysis has been observed. Types of severe renal adverse events that have been seen following IGIV therapy include acute renal failure, acute tubular necrosis, proximal tubular nephropathy and osmotic nephrosis.18-25

Severe reactions such as angioneurotic edema and anaphylactic shock, although not observed during clinical trials, are a possibility. Clinical anaphylaxis may occur even when the patient is not known to be sensitized to immune globulin products. A reaction may be related to the rate of infusion; therefore, carefully adhere to the infusion rates as outlined under DOSAGE AND ADMINISTRATION. If anaphylaxis or drop in blood pressure occurs, discontinue infusion and use antidote such as diphenhydramine and adrenalin.

Postmarketing

The following adverse reactions have been identified and reported during the post-approval use of IGIV products:38

Respiratory: Apnea, Acute Respiratory Distress Syndrome (ARDS), Transfusion-Related Acute Lung Injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, bronchospasm

Cardiovascular: Cardiac arrest, thromboembolism, vascular collapse, hypotension

Neurological: Coma, loss of consciousness, seizures, tremor

Integumentary: Stevens-Johnson syndrome, epidermolysis, erythema multiforme, bullous dermatitis

Hematologic: Pancytopenia, leukopenia, hemolysis, positive direct antiglobulin (Coombs) test

General/Body as a Whole: Pyrexia, Rigors

Musculoskeletal: Back paink

Gastrointestinal: Hepatic dysfunction, abdominal pain

Because postmarketing reporting of these reactions is voluntary and the at-risk populations are of uncertain size, it is not always possible to reliably estimate the frequency of the reaction or establish a causal relationship to exposure to the product. Such is also the case with literature reports authored independently.

Read the entire FDA prescribing information for Cytogam (Cytomegalovirus Immune Globulin Intravenous Human)

© Cytogam Patient Information is supplied by Cerner Multum, Inc. and Cytogam Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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