Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Danocrine vs. Lupron

Are Danocrine and Lupron the Same Thing?

Danazol and Lupron Injection (leuprolide acetate) are used to treat symptoms of endometriosis.

Danazol is also used to treat breast pain/tenderness/nodules due to fibrocystic breast disease.

Lupron is also used in women to treat symptoms of uterine fibroids, in men to treat symptoms of prostate cancer, and in male and female children to treat precocious (early-onset) puberty.

A brand name of danazol is Danocrine.

Danazol and Lupron belong to different drug classes. Danazol is a steroid and Lupron is a gonadotropin-releasing hormone.

Side effects of danazol and Lupron that are similar include acne, flushing, sweating, vaginal discomfort/dryness/irritation/burning/itching, or depression.

Side effects of danazol that are different from Lupron include weight gain, oily skin or hair, hair loss, voice changes (hoarseness, changes in pitch), sore throat, abnormal growth of body hair (in women), decreased breast size, water retention or bloating, irritability, changes in menstrual cycle (spotting, irregular bleeding, missed periods), nervousness, and mood changes.

Side effects of Lupron that are different from danazol include redness/burning/stinging/pain/bruising at the injection site, hot flashes, night sweats, tiredness, headache, upset stomach, nausea, diarrhea, constipation, stomach pain, breast swelling or tenderness, joint/muscle aches or pain, trouble sleeping (insomnia), reduced sexual interest, vaginal discharge or bleeding, swelling of the ankles/feet, increased urination at night, dizziness, breakthrough bleeding in a female child during the first 2 months of leuprolide treatment, weakness, chills, clammy skin, skin redness, itching or scaling, testicle pain, impotence, increased growth of facial hair, or memory problems.

Danazol may interact with warfarin, carbamazepine, antidiabetic drugs, cyclosporine, tacrolimus, synthetic vitamin D analogs, and statins.

Lupron may interact with antibiotics, antifungal medicines, antidepressants, anti-malaria medicines, asthma inhalers, antipsychotic medicines, cancer medicines, certain HIV/AIDS medicines, heart or blood pressure medicines, or medicines to prevent vomiting.

What Are Possible Side Effects of Danocrine?

Side effects of Danocrine include:

  •  acne or other skin problems
  • increased hair growth or hair loss
  • weight gain
  • breast changes
  • deepened voice
  • hoarseness
  • sore throat
  • nervousness
  •  increased sweating
  • flushing (warmth, redness, or tingly feeling under your skin
  • decreased amount of semen released during sex
  • changes in your menstrual periods
  • unusual vaginal bleeding or spotting,
  • or vaginal dryness/discomfort/itching

What Are Possible Side Effects of Lupron?

Common side effects of Lupron include:

  • redness/burning/stinging/pain/bruising at the injection site,
  • hot flashes (flushing),
  • increased sweating,
  • night sweats,
  • tiredness,
  • headache,
  • upset stomach,
  • nausea,
  • diarrhea,
  • constipation,
  • stomach pain,
  • breast swelling or tenderness,
  • acne,
  • joint/muscle aches or pain,
  • trouble sleeping (insomnia),
  • reduced sexual interest,
  • vaginal discomfort/dryness/itching/discharge,
  • vaginal bleeding,
  • swelling of the ankles/feet,
  • increased urination at night,
  • dizziness,
  • breakthrough bleeding in a female child during the first 2 months of leuprolide treatment,
  • weakness,
  • chills,
  • clammy skin,
  • skin redness,
  • itching or scaling,
  • testicle pain,
  • impotence,
  • depression,
  • increased growth of facial hair, or
  • memory problems.

What Is Danocrine?

Danocrine (danazol) is a steroid used to treat endometriosis and fibrocystic breast disease. Danocrine is also used to prevent attacks of angioedema in people with an inherited form of this disorder.

What Is Lupron?

Lupron Injection (leuprolide acetate) is a synthetic gonadotropin-releasing hormone used in men to treat symptoms of prostate cancer, and in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids. Lupron Injection is also used to treat precocious (early-onset) puberty in both male and female children.

SLIDESHOW

What Is Endometriosis? Symptoms, Causes, Treatment See Slideshow

What Drugs Interact With Danocrine?

Danocrine may interact with blood thinners, or carbamazepine. Tell your doctor all medications and supplements you use. Danocrine can cause birth defects. Do not use Danocrine if you are pregnant. Tell your doctor if you become pregnant during treatment. Before you start taking Danocrine, you may need to have a pregnancy test to make sure you are not pregnant. Use an effective barrier form of birth control (such as a condom or diaphragm with spermicide gel or inserts). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective to prevent pregnancy during treatment. Breastfeeding is not recommended while using this drug.

What Drugs Interact With Lupron?

There may be other drugs that can interact with Lupron Injection.

How Should Danocrine Be Taken?

In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg Danocrine given in two divided doses is recommended. The total daily dosage of Danocrine for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response.

How Should Lupron Be Taken?

Dosage of Lupron Injection depends on the condition being treated, and the patient's age and sex.

QUESTION

Endometriosis occurs deep inside the uterus. See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
SOURCES:

DailyMed. Danazol Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e19acee5-ff33-45a5-bbbf-801756bc59b4

AbbVie Inc. Lupron Product Information.

http://www.lupron.com/

Health Solutions From Our Sponsors