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Last reviewed on RxList: 3/30/2017
Daraprim Side Effects Center

Last reviewed on RxList 02/21/2017

Daraprim (pyrimethamine) is an antiparasitic drug used to treat and prevent malaria, and is also used in the treatment of toxoplasmosis. Common side effects of Daraprim include:

Some people using Daraprim may develop serious side effects including blood problems, especially at higher doses. Tell your doctor if you have symptoms of blood problems including: easy bruising or bleeding, signs of serious infection (such as high fever, severe chills, persistent sore throat), signs of low red blood cell count (such as severe tiredness, pale lips/nails/skin, fast heartbeat/breathing with usual activities), or swollen or painful tongue.

The adult starting dose of Daraprim to treat toxoplasmosis is 50 to 75 mg daily, taken with 1 to 4 g daily of a sulfonamide of the sulfapyrimidine type. Pediatric dose to treat toxoplasmosis is determined by the child's weight. The adult dosage for acute malaria is 50 mg for 2 days; children 4 through 10 years old may be given 25 mg daily for 2 days. Daraprim may interact with auranofin, aurothioglucose, or gold sodium thiomalate. Tell your doctor all medications you use. During pregnancy, Daraprim should be used only when prescribed. Folic acid is very important during pregnancy. Your doctor will prescribe folic/folinic acid to prevent low folate levels. This medication passes into breast milk. Consult your doctor before breastfeeding.

Our Daraprim (pyrimethamine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Daraprim Consumer Information

Stop taking pyrimethamine and seek emergency medical attention if you experience an allergic reaction (swelling of the lips, tongue, or face; difficulty breathing; closing of the throat; or hives) during treatment with pyrimethamine.

Stop taking pyrimethamine and seek medical attention at the first sign of a skin rash, sore throat, paleness of the skin, unusual bruising under the skin, or swelling of the tongue. These may be early symptoms of serious side effects of pyrimethamine.

Other, less serious side effects may be more likely to occur. Continue to take pyrimethamine and talk to your doctor if you experience

  • nausea, vomiting, or loss of appetite;
  • insomnia;
  • headache;
  • lightheadedness; or
  • dryness of the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Daraprim (Pyrimethamine)

Daraprim Professional Information


Hypersensitivity reactions, occasionally severe (such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and anaphylaxis), and hyperphenylalaninemia, can occur particularly when pyrimethamine is administered concomitantly with a sulfonamide. Consult the complete prescribing information for the relevant sulfonamide for sulfonamideassociated adverse events. With doses of pyrimethamine used for the treatment of toxoplasmosis, anorexia and vomiting may occur. Vomiting may be minimized by giving the medication with meals; it usually disappears promptly upon reduction of dosage. Doses used in toxoplasmosis may produce megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, neutropenia, atrophic glossitis, hematuria, and disorders of cardiac rhythm.

Hematologic effects, however, may also occur at low doses in certain individuals (see PRECAUTIONS; General). Pulmonary eosinophilia has been reported rarely.

Read the entire FDA prescribing information for Daraprim (Pyrimethamine)

Related Resources for Daraprim

Read the Daraprim User Reviews »

© Daraprim Patient Information is supplied by Cerner Multum, Inc. and Daraprim Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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