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Darvon Compound

Last reviewed on RxList: 11/29/2016
Darvon Compound Side Effects Center

Last reviewed on RxList 5/6/2016

Darvon Compound (propoxyphene hydrochloride, aspirin, caffeine) is a combination of a narcotic pain reliever, aspirin, and caffeine used to treat moderate-to-severe pain. The brand name Darvon Compound is discontinued, but generic versions may be available. Common side effects of Darvon Compound (propoxyphene hydrochloride, aspirin, caffeine) include:

The usual dosage of Darvon Compound is 65 mg propoxyphene hydrochloride, 389 mg aspirin and 32.4 mg caffeine (one capsule) every 4 hours as needed for pain. Darvon Compound may interact with anticoagulants, carbamazepine, monoamine oxidase inhibitors (MAOIs), antidepressants, alcohol, antihistamines, sedatives, other pain relievers, anxiety medicines, muscle relaxants, or over-the-counter and prescription products containing aspirin. Tell your doctor all medications and supplements you use. The propoxyphene in Darvon Compound may cause addiction and withdrawal symptoms as well as other harmful effects in a fetus. Do not take Darvon Compound without first talking to your doctor if you are pregnant or could become pregnant during treatment. Propoxyphene may also cause addiction and withdrawal symptoms in a nursing baby. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Our Darvon Compound (propoxyphene hydrochloride, aspirin, caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Darvon Compound Consumer Information

If you experience any of the following serious side effects, stop taking aspirin/caffeine/propoxyphene and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • slow, weak breathing;
  • seizures;
  • cold, clammy skin;
  • severe weakness or dizziness;
  • unconsciousness; or
  • black, bloody, or tarry stools or blood in your urine or vomit.

Other, less serious side effects may be more likely to occur. Continue to take aspirin/caffeine/propoxyphene and talk to your doctor if you experience

  • constipation;
  • dry mouth, nausea, vomiting, or decreased appetite;
  • dizziness, tiredness, or lightheadedness;
  • muscle twitches;
  • sweating;
  • itching
  • decreased urination;
  • decreased sex drive; or
  • ringing in the ears.

Propoxyphene may be habit forming. Physical and/or psychological dependence can occur, and withdrawal effects are possible if the medication is stopped suddenly after prolonged or high-dose treatment. Do not stop taking aspirin/caffeine/propoxyphene suddenly without first talking to your doctor if you have been taking it continuously for more than 5 to 7 days. Your doctor may want to gradually reduce the dose.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Darvon Compound (Propoxyphene, Aspirin, and Caffeine)

Darvon Compound Professional Information


In a survey conducted in hospitalized patients less than 1% of patients taking propoxyphene hydrochloride at recommended doses experienced side effects. The most frequently reported were dizziness, sedation, nausea and vomiting. Some of these adverse reactions may be alleviated if the patient lies down.

Other adverse reactions include constipation, abdominal pain, skin rashes, lightheadedness, headache, weakness, euphoria, dysphoria hallucinations, and minor visual disturbances.

Propoxyphene therapy has been associated with abnormal liver function tests and more rarely with instances of reversible jaundice (including cholestatic jaundice).

Renal papillary necrosis may result from chronic aspirin use, particularly when the dosage is greater than recommended and when combined with acetaminophen.

Subacute painful myopathy has occurred following chronic propoxyphene overdosage.

Read the entire FDA prescribing information for Darvon Compound (Propoxyphene, Aspirin, and Caffeine)

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© Darvon Compound Patient Information is supplied by Cerner Multum, Inc. and Darvon Compound Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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