Daurismo vs. Oncaspar

Daurismo (glasdegib) and Oncaspar (pegaspargase) is a cancer (antineoplastic) medications used to treat different types of leukemia.

Daurismo is indicated, in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients who are 75 years old or older or who have comorbidities that preclude use of intensive induction chemotherapy.

Oncaspar is used to treat acute lymphoblastic leukemia.

Daurismo and Oncaspar are different types of cancer (antineoplastic) medications. Daurismo is a hedgehog pathway inhibitor and Oncaspar is a tetrameric enzyme.

Side effects of Daurismo and Oncaspar that are similar include fatigue/tiredness, nausea, fluid retention/swelling, decreased appetite, skin rash, diarrhea, vomiting, dizziness, headache, abdominal pain/stomach cramps, and weight loss.

Side effects of Daurismo that are different from Oncaspar include anemia, bleeding, febrile neutropenia, musculoskeletal pain, low blood platelets (thrombocytopenia), shortness of breath, changes in taste, inflammation and ulcers of mucus membranes, constipation, fever, chest pain, muscle spasm, cough, pneumonia, low blood sodium (hyponatremia), decreased white blood cell count, irregular heart rate, and kidney problems.

Side effects of Oncaspar that are different from Daurismo include weakness, itching, depression, drowsiness, irritability, and injection site reactions (pain swelling or redness).

Daurismo may interact with strong CYP3A inhibitors or inducers, QTc prolonging drugs, other medicines for infections, asthma medications, medicines to treat heart problems, medications for high blood pressure, antidepressants, drugs to treat mental illness, anti-cancer drugs, anti-malaria medications, and HIV medicines.

Oncaspar may interact with vincristine, prednisone, or methotrexate.

Side effects of Daurismo include:

• nervousness,
• shaking (tremor),
• headache,
• dizziness,
• mouth/throat dryness or irritation,
• sore throat,
• cough,
• nausea,
• vomiting,
• dizziness,
• sleep problems (insomnia),
• hoarseness,
• runny or stuffy nose,
• muscle pain, or
• diarrhea

Common side effects of Oncaspar include:

• nausea
• vomiting
• weakness
• loss of appetite
• diarrhea
• dizziness
• skin rash or itching
• depression
• drowsiness
• swelling in your hands/ankles/feet
• weight loss
• stomach cramps
• headache
• tiredness
• irritability
• injection site reactions (pain swelling or redness).

Daurismo is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs used to prevent and treat wheezing and shortness of breath caused by breathing problems such as asthma and chronic obstructive pulmonary disease. Daurismo is also used to prevent exercise-induced asthma.

Oncaspar (pegaspargase) is a cancer (antineoplastic) medication used to treat acute lymphoblastic leukemia.

Daurismo may interact with other inhaled medicines, other asthma medicines, beta-blockers, diuretics, digoxin, monoamine oxidase inhibitors (MAOIs), and antidepressants. Tell your doctor all medications and supplements you use.

Oncaspar may interact with vincristine, prednisone, or methotrexate. Tell your doctor all medications and supplements you use.

Daurismo is a dry powder inhaler supplied for 200 measured inhalation doses.

The recommended dose of Oncaspar is 2,500 IU/m² intramuscularly (IM) or intravenously (IV). It should be administered no more frequently than every 14 days.