Dayvigo vs. Lunesta

• Dayvigo (lemborexant) and Lunesta (eszopiclone) are used to treat insomnia.
• Dayvigo and Lunesta belong to different drug classes.
  • Dayvigo is an orexin receptor antagonist and
  • Lunesta is a sedative-hypnotic.
• Side effects of Dayvigo and Lunesta that are similar include drowsiness and headache.
• Side effects of Dayvigo that are different from Lunesta include nightmares or abnormal dreams.
• Side effects of Lunesta that are different from Dayvigo include dizziness, "hangover" feeling, problems with memory or concentration, anxiety, depression, nervous feeling, nausea, stomach pain, loss of appetite, constipation, dry mouth, unusual or unpleasant taste in your mouth, and mild skin rash.
• Both Dayvigo and Lunesta may interact with alcohol and rifampin.
• Dayvigo may also interact with itraconazole, clarithromycin, fluconazole, verapamil, carbamazepine, St. John's wort, bosentan, efavirenz, etravirine, modafinil, chlorzoxazone, ranitidine, bupropion, and methadone.
• Lunesta may also interact with other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxants, and medicine for depression or anxiety), ketoconazole, narcotic pain medications, and seizure medications.
• Lunesta may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses.

Common side effects of Dayvigo include:

• drowsiness,
• headache, and
• nightmares or abnormal dreams

Common side effects of Lunesta include:

• dizziness,
• tiredness,
• daytime drowsiness (or during hours when you are not normally sleeping),
• loss of coordination,
• headache,
• depression,
• memory problems,
• numbness or tingly feeling,
• nervousness,
• excitability,
• irritability,
• changes in menstrual periods,
• itching,
• increased or decreased interest in sex, or
• blurred vision.

Tell your doctor if you have serious side effects of Lunesta including:

• memory loss, or
• mental/mood/behavior changes (such as new or worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, or anxiety).

Rarely, after taking Lunesta, people have gotten out of bed and driven vehicles while not fully awake ("sleep-driving"). People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Often, these people do not remember these events. This problem can be dangerous to you or to others. If you find out that you have done any of these activities after taking Lunesta, tell your doctor right away.

Dayvigo (lemborexant) is an orexin receptor antagonist used to treat adult patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.

Lunesta (eszopiclone) is a sedative hypnotic used to treat insomnia.

Dayvigo may interact with other medicines such as:

• itraconazole,
• clarithromycin,
• fluconazole,
• verapamil,
• rifampin,
• carbamazepine,
• St. John’s wort,
• bosentan,
• efavirenz,
• etravirine,
• modafinil,
• alcohol,
• bupropion, and
• methadone

Tell your doctor about all medications and supplements you use.

Lunesta may interact with alcohol, other medicines that make you sleepy or slow your breathing (such as cold medicines, pain medications, muscle relaxants, and medicines for depression, anxiety, or seizures), ketoconazole, rifampin, or antidepressants.

• The recommended dose of Dayvigo is 5 mg taken no more than once per night, immediately before going to bed, with at least 7 hours remaining before the planned time of awakening.
• The dosage of Dayvigo may be increased to 10 mg based on clinical response and tolerability.

The recommended starting dose of Lunesta is 1 mg, taken with a full glass of water. Avoid taking Lunesta within 1 hour after eating a high-fat or heavy meal, because this will make it harder for your body to absorb the medication.

Because many drugs are excreted in human milk, caution should be exercised when Lunesta is administered to a nursing woman. A doctor should be consulted both before becoming pregnant and before nursing while taking Lunesta. This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as anxiety, abdominal cramps, vomiting, sweating, or shakiness) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions immediately.