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DDAVP Injection

Last reviewed on RxList: 6/27/2017
DDAVP Injection Side Effects Center

Last reviewed on RxList 6/27/2017

DDAVP Injection (desmopressin acetate) is a man-made form of a hormone that occurs naturally in the pituitary gland used to treat hemophilia A or von Willebrand's disease Type I, and is also used to treat central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma. DDAVP Injection is available in generic form. Common side effects of DDAVP Injection include:

  • headache,
  • nausea,
  • upset stomach,
  • stomach pain,
  • diarrhea,
  • flushing of the face (warmth, redness, or tingly feeling), or
  • injection site reactions (redness, pain, or swelling).

DDAVP Injection can infrequently cause a low level of sodium in the blood, which can be serious and possibly life-threatening. Seek immediate medical attention if you have unlikely but serious symptoms of a low level of sodium in the blood such as:

  • loss of appetite,
  • severe nausea,
  • vomiting,
  • severe headache,
  • muscle weakness/spasms/cramps,
  • sudden weight gain,
  • unusual tiredness,
  • unusual severe drowsiness,
  • mental/mood changes (such as confusion, hallucinations, irritability),
  • loss of consciousness,
  • seizures, or
  • slow or shallow breathing.

The dose of DDAVP Injection to treat hemophilia A and von Willebrand's Disease Type I is 4 mcg/mL administered as an intravenous infusion at a dose of 0.3 mcg DDAVP/kg body weight diluted in saline and infused slowly over 15 to 30 minutes. DDAVP Injection may interact with carbamazepine, chlorpromazine, lamotrigine, oxybutynin, vasopressin, narcotics, antidepressants, medicines to treat erectile dysfunction, drugs to treat high blood pressure or prostate disorder, beta-blockers, or NSAIDs (nonsteroidal anti-inflammatory drugs).Tell your doctor all medications and supplements you use. During pregnancy, DDAVP Injection should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our DDAVP Injection (desmopressin acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

DDAVP Injection Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using desmopressin and call your doctor at once if you have any of these serious side effects:

  • nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;
  • feeling like you might pass out;
  • swelling;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, headache, confusion, or problems with vision, speech, or balance;
  • vaginal pain; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • headache;
  • nausea, mild stomach pain;
  • diarrhea;
  • warmth, redness, or tingly feeling in your face; or
  • pain, redness, or swelling where the medicine was injected.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for DDAVP Injection (Desmopressin Acetate Injection)

DDAVP Injection Professional Information


Infrequently, DDAVP has produced transient headache, nausea, mild abdominal cramps and vulval pain. These symptoms disappeared with reduction in dosage. Occasionally, injection of DDAVP has produced local erythema, swelling or burning pain. Occasional facial flushing has been reported with the administration of DDAVP. DDAVP Injection (desmopressin acetate injection) has infrequently produced changes in blood pressure causing either a slight elevation or a transient fall and a compensatory increase in heart rate. Severe allergic reactions including anaphylaxis have been reported rarely with DDAVP Injection.

See WARNINGS for the possibility of water intoxication and hyponatremia.

Post Marketing: There have been rare reports of thrombotic events (acute cerebrovascular thrombosis, acute myocardial infarction) following DDAVP Injection in patients predisposed to thrombus formation, and rare reports of hyponatremic convulsions associated with concomitant use with the following medications: oxybutinin and imipramine.

Read the entire FDA prescribing information for DDAVP Injection (Desmopressin Acetate Injection)

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© DDAVP Injection Patient Information is supplied by Cerner Multum, Inc. and DDAVP Injection Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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