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DDAVP Nasal Spray

Last reviewed on RxList: 6/27/2017
DDAVP Nasal Spray Side Effects Center

Last reviewed on RxList 6/27/2017

DDAVP Nasal Spray (desmopressin acetate) is a man-made form of a hormone that occurs naturally in the pituitary gland used to treat central cranial diabetes insipidus, increased thirst and urination caused by head surgery or head trauma, hemophilia A, or von Willebrand's disease Type I. DDAVP Nasal Spray is available in generic form. Common side effects of DDAVP Nasal Spray include:

  • headache,
  • runny or stuffy nose,
  • nausea,
  • vomiting,
  • upset stomach,
  • stomach pain,
  • flushing (warmth, redness, or tingly feeling) of the face,
  • sore throat,
  • cough,
  • other cold symptoms,
  • eye redness or watering,
  • eye itching,
  • increased sensitivity to light,
  • weakness,
  • dizziness,
  • agitation, or
  • hot or cold feeling.

DDAVP Nasal Spray can infrequently cause a low level of sodium in the blood, which can be serious and possibly life-threatening. Drinking too much water or other fluids increases the risk of having a low level of sodium in the blood. Follow your doctor's directions for limiting fluids. Seek immediate medical attention if you have unlikely but serious symptoms of a low level of sodium in the blood while taking DDAVP Nasal Spray including loss of appetite, severe nausea or vomiting, severe headache, muscle weakness/spasms/cramps, sudden weight gain, unusual tiredness, unusual severe drowsiness, mental/mood changes (such as confusion, hallucinations, irritability), loss of consciousness, seizures, or slow or shallow breathing.

The usual dosage range of DDAVP Nasal Spray in adults is 0.1 to 0.4 mL daily, either as a single dose or divided into two or three doses. For children aged 3 months to 12 years, the usual dosage range is 0.05 to 0.3 mL daily, either as a single dose or divided into two doses. DDAVP Nasal Spray may interact with carbamazepine, chlorpromazine, lamotrigine, oxybutynin, vasopressin, narcotics, antidepressants, antidepressants, medicine to treat erectile dysfunction, drugs to treat high blood pressure or a prostate disorder, beta-blockers, or NSAIDs (nonsteroidal anti-inflammatory drugs). During pregnancy, DDAVP Nasal Spray should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our DDAVP Nasal Spray (desmopressin acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

DDAVP Nasal Spray Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using desmopressin nasal and call your doctor at once if you have any of these serious side effects:

  • nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;
  • feeling like you might pass out;
  • swelling;
  • chest pain, fast or pounding heart rate;
  • vaginal pain;
  • nosebleed; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • runny or stuffy nose;
  • sore throat, cough, or other cold symptoms;
  • eye redness or watering;
  • eye itching or increased sensitivity to light;
  • headache, weakness;
  • feeling dizzy or agitated;
  • nausea, vomiting, stomach pain;
  • hot or cold feeling; or
  • warmth, redness, or tingly feeling in your face.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for DDAVP Nasal Spray (Desmopressin Acetate Nasal Spray)

DDAVP Nasal Spray Professional Information


Infrequently, high dosages of intranasal DDAVP have produced transient headache and nausea. Nasal congestion, rhinitis and flushing have also been reported occasionally along with mild abdominal cramps. These symptoms disappeared with reduction in dosage. Nosebleed, sore throat, cough and upper respiratory infections have also been reported.

The following table lists the percentage of patients having adverse experiences without regard to relationship to study drug from the pooled pivotal study data for nocturnal enuresis.

20 mcg
40 mcg
  % % %
  Abdominal Pain 0 2 2
  Asthenia 0 0 2
  Chills 0 0 2
  Headache 0 2 5
  Dizziness 0 0 3
  Epistaxis 2 3 0
  Nostril Pain 0 2 0
  Rhinitis 2 8 3
  Gastrointestinal Disorder 0 2 0
  Nausea 0 0 2
  Conjunctivitis 0 2 0
  Edema Eyes 0 2 0
  Lachrymation Disorder 0 0 2

Post Marketing: There have been rare reports of hyponatremic convulsions associated with concomitant use with the following medications: oxybutinin and imipramine.

See WARNINGS for the possibility of water intoxication and hyponatremia.

Read the entire FDA prescribing information for DDAVP Nasal Spray (Desmopressin Acetate Nasal Spray)

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© DDAVP Nasal Spray Patient Information is supplied by Cerner Multum, Inc. and DDAVP Nasal Spray Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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