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Last reviewed on RxList: 6/27/2017
DDAVP Side Effects Center

Last reviewed on RxList 6/27/2017

DDAVP (desmopressin acetate) is an antidiuretic and antihemorrhagic drug used to treat bed-wetting, central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma. DDAVP is also used to treat bleeding due to platelet dysfunction. DDAVP is available in generic form. Common side effects of DDAVP include:

  • headache,
  • nausea,
  • upset stomach or stomach pain,
  • diarrhea, or
  • flushing of the face (warmth, redness, tingly feeling).

DDAVP can infrequently cause low levels of sodium in the blood, which can be serious and possibly life-threatening. Seek immediate medical attention if you have symptoms of low levels of sodium in the blood, including:

  • loss of appetite,
  • nausea,
  • vomiting,
  • severe headache,
  • muscle weakness/spasms/cramps,
  • weight gain,
  • unusual tiredness,
  • dizziness,
  • severe drowsiness,
  • mental/mood changes (confusion, hallucinations, irritability),
  • loss of consciousness,
  • seizures, or
  • slow/shallow breathing.

The dosage of DDAVP is determined for each patient and adjusted according to the response. Usual starting dose is 0.05 mg twice/day and increased to a dosage range of 0.1 mg to 0.8 mg daily. DDAVP may interact with carbamazepine, chlorpromazine, lamotrigine, oxybutynin, vasopressin, narcotic pain medicine, antidepressants, medicine to treat erectile dysfunction, drugs to treat high blood pressure or a prostate disorder, beta-blockers, or NSAIDs (non-steroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. During pregnancy, DDAVP should be used only when prescribed. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

Our DDAVP Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

DDAVP Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking desmopressin and call your doctor at once if you have any of these serious side effects:

  • nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;
  • feeling like you might pass out;
  • swelling, weight gain; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • headache;
  • nausea, mild stomach pain;
  • diarrhea; or
  • warmth, redness, or tingly feeling in your face.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for DDAVP (Desmopressin Acetate Tablets)

DDAVP Professional Information


Infrequently, large doses of the intranasal formulations of DDAVP (desmopressin acetate tablets) and DDAVP (desmopressin acetate tablets) Injection have produced transient headache, nausea, flushing and mild abdominal cramps. These symptoms have disappeared with reduction in dosage.

Central Diabetes Insipidus: In long-term clinical studies in which patients with diabetes insipidus were followed for periods up to 44 months of DDAVP (desmopressin acetate tablets) Tablet therapy, transient increases in AST (SGOT) no higher than 1.5 times the upper limit of normal were occasionally observed. Elevated AST (SGOT) returned to the normal range despite continued use of DDAVP (desmopressin acetate tablets) Tablets.

Primary Nocturnal Enuresis: The only adverse event occurring in ≥ 3% of patients in controlled clinical trials with DDAVP (desmopressin acetate tablets) Tablets that was probably, possibly, or remotely related to study drug was headache (4% DDAVP (desmopressin acetate tablets) , 3% placebo).

Other: The following adverse events have been reported; however their relationship to DDAVP (desmopressin acetate tablets) has not been established: abnormal thinking, diarrhea, and edema-weight gain.

See WARNINGS for the possibility of water intoxication and hyponatremia.

Post Marketing: There have been rare reports of hyponatremic convulsions associated with concomitant use with the following medications: oxybutinin and imipramine.

Read the entire FDA prescribing information for DDAVP (Desmopressin Acetate Tablets)

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© DDAVP Patient Information is supplied by Cerner Multum, Inc. and DDAVP Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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