Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 1/26/2022
Declomycin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Declomycin?

Declomycin (demeclocycline hydrochloride) Tablets is an antibiotic used to treat bacterial infections including those that cause acne.

What Are Side Effects of Declomycin?

Common side effects of Declomycin include:

Tell your doctor if you have unlikely but serious side effects of Declomycin including:

  • sunburn-like skin reaction (sun sensitivity),
  • darkening of the skin and other areas of the body (e.g., lips, inside of the mouth),
  • painful swallowing,
  • unusual increase in the amount of urine (except for the expected increase in urination if you are treating SIADH),
  • unusual decrease in the amount of urine or no urine,
  • unusual thirst,
  • weakness,
  • unusual tiredness, or
  • brown or gray tooth discoloration.

Dosage for Declomycin

The recommended dose of Declomycin is 600 mg divided into two to four doses per day.

What Drugs, Substances, or Supplements Interact with Declomycin?

Colestid, Trexall, Accutane, vitamin A, Renova, antacids, warfarin, birth control pills, and penicillin antibiotics may interact with Declomycin. Tell your doctor all medications you take. Avoid exposure to sunlight or tanning beds. Do not give Declomycin to children under 8 years of age.

Declomycin During Pregnancy or Breastfeeding

Do not take Declomycin if you are pregnant or breastfeeding.

Additional Information

Our Declomycin (demeclocycline hydrochloride) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Bowel regularity means a bowel movement every day. See Answer
Declomycin Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • new or worsening cough, fever, trouble breathing;
  • painful swallowing, vomiting blood (avoid lying down right after taking demeclocycline);
  • kidney problems--swelling, urinating less, feeling tired or short of breath;
  • low blood cell counts--fever, chills, tiredness, confusion or weakness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, vomiting, diarrhea, loss of appetite;
  • darkened skin color;
  • swollen tongue, trouble swallowing; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Declomycin (Demeclocycline HCl)


Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow
Declomycin Professional Information


The following reactions have been reported in patients receiving tetracyclines:

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, increases in liver enzymes, and hepatic toxicity has been reported rarely.

Rarely, hepatitis and liver failure have been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines.

Instances of esophageal ulcerations have been reported in patients receiving oral tetracyclines. Most of the patients were reported to have taken the medication immediately before lying down. (See DOSAGE AND ADMINISTRATION.)

Skin: Maculopapular and erythematous rashes, erythema multiforme. Exfoliative dermatitis has been reported but is uncommon. Fixed drug eruptions and Stevens-Johnson syndrome have been reported rarely. Lesions occurring on the glans penis have caused balanitis. Pigmentation of the skin and mucous membranes has also been reported. Photosensitivity is discussed above. (See WARNINGS.)

Renal toxicity: Acute renal failure. Rise in BUN has been reported and is apparently dose related. Nephrogenic diabetes insipidus. (See WARNINGS.)

Hypersensitivity reactions: Urticaria, angioneurotic edema, polyarthralgia, anaphylaxis, anaphylactoid purpura, pericarditis exacerbation of systemic lupus erythematosus, lupus-like syndrome, pulmonary infiltrates with eosinophilia.

Hematologic: Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia have been reported.

CNS: Pseudotumor cerebri (benign intracranial hypertension) in adults and bulging fontanels in infants (see PRECAUTIONSGeneral). Dizziness, headache, tinnitus, and visual disturbances have been reported. Myasthenic syndrome has been reported rarely.

Other: When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function studies are known to occur. Very rare cases of abnormal thyroid function have been reported.

Tooth discoloration has occurred in pediatric patients less than 8 years of age (see WARNINGS), and has been reported rarely in adults.

Read the entire FDA prescribing information for Declomycin (Demeclocycline HCl)

© Declomycin Patient Information is supplied by Cerner Multum, Inc. and Declomycin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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