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Last reviewed on RxList: 3/30/2017
Declomycin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 02/16/2017

Declomycin (demeclocycline hydrochloride) Tablets is an antibiotic used to treat bacterial infections including those that cause acne. Common side effects of Declomycin include:

Tell your doctor if you have unlikely but serious side effects of Declomycin including:

  • sunburn-like skin reaction (sun sensitivity),
  • darkening of the skin and other areas of the body (e.g., lips, inside of the mouth),
  • painful swallowing,
  • unusual increase in the amount of urine (except for the expected increase in urination if you are treating SIADH),
  • unusual decrease in the amount of urine or no urine,
  • unusual thirst,
  • weakness,
  • unusual tiredness, or
  • brown or gray tooth discoloration.

The recommended dose of Declomycin is 600 mg divided into two to four doses per day. Colestid, Trexall, Accutane, vitamin A, Renova, antacids, warfarin, birth control pills, and penicillin antibiotics may interact with Declomycin. Tell your doctor all medications you take. Avoid exposure to sunlight or tanning beds. Do not give Declomycin to children under 8 years of age. Do not take Declomycin if you are pregnant or breastfeeding.

Our Declomycin (demeclocycline hydrochloride) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Declomycin Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using demeclocycline and call your doctor at once if you have a serious side effect such as:

  • fever, chills, body aches, flu symptoms;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • pale skin, dark colored urine, jaundice (yellowing of the skin or eyes);
  • confusion, mood changes, weakness, increased thirst or urination;
  • swelling, weight gain, urinating less than usual or not at all;
  • chest pain, wheezing, dry cough, rapid breathing, feeling short of breath;
  • severe tingling, numbness, pain, muscle weakness;
  • headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;
  • sore throat and headache with a severe blistering, peeling, and red skin rash; or
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

Less serious side effects may include:

  • sores or swelling in your rectal or genital area;
  • mild nausea, vomiting, diarrhea, loss of appetite;
  • white patches or sores inside your mouth or on your lips;
  • swollen tongue, trouble swallowing; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Declomycin (Demeclocycline HCl)

Declomycin Professional Information


The following reactions have been reported in patients receiving tetracyclines:

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, increases in liver enzymes, and hepatic toxicity has been reported rarely.

Rarely, hepatitis and liver failure have been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines.

Instances of esophageal ulcerations have been reported in patients receiving oral tetracyclines. Most of the patients were reported to have taken the medication immediately before lying down. (See DOSAGE AND ADMINISTRATION.)

Skin: Maculopapular and erythematous rashes, erythema multiforme. Exfoliative dermatitis has been reported but is uncommon. Fixed drug eruptions and Stevens-Johnson syndrome have been reported rarely. Lesions occurring on the glans penis have caused balanitis. Pigmentation of the skin and mucous membranes has also been reported. Photosensitivity is discussed above. (See WARNINGS.)

Renal toxicity: Acute renal failure. Rise in BUN has been reported and is apparently dose related. Nephrogenic diabetes insipidus. (See WARNINGS.)

Hypersensitivity reactions: Urticaria, angioneurotic edema, polyarthralgia, anaphylaxis, anaphylactoid purpura, pericarditis exacerbation of systemic lupus erythematosus, lupus-like syndrome, pulmonary infiltrates with eosinophilia.

Hematologic: Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia have been reported.

CNS: Pseudotumor cerebri (benign intracranial hypertension) in adults and bulging fontanels in infants (see PRECAUTIONS - General). Dizziness, headache, tinnitus, and visual disturbances have been reported. Myasthenic syndrome has been reported rarely.

Other: When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function studies are known to occur. Very rare cases of abnormal thyroid function have been reported.

Tooth discoloration has occurred in pediatric patients less than 8 years of age (see WARNINGS), and has been reported rarely in adults.

Read the entire FDA prescribing information for Declomycin (Demeclocycline HCl)

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© Declomycin Patient Information is supplied by Cerner Multum, Inc. and Declomycin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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