Brand Names: Clinagen LA 40, Delestrogen, Dep Gynogen, Depo-Estradiol, Depogen, Dioval 40, Dioval XX, Dura-Estrin, Duragen, Estra-C, Estra-V 40, Estragyn LA 5, Estro-Cyp, Estro-Span 40, Gynogen LA 20, Medidiol 10, Menaval-20, Valergen
Generic Name: estradiol (injection)
- What is estradiol injection?
- What are the possible side effects of estradiol injection?
- What is the most important information I should know about estradiol injection?
- What should I discuss with my health care provider before using estradiol injection?
- How is estradiol injection given?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid while using estradiol injection?
- What other drugs will affect estradiol injection?
- Where can I get more information?
What is estradiol injection?
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.
Estradiol injection is used to treat certain symptoms of menopause such as hot flashes and vaginal dryness, burning, or irritation. It is also used to treat a lack of estrogen that is caused by ovarian failure or a condition called hypogonadism.
Estradiol injection may also be used for purposes not listed in this medication guide.
What are the possible side effects of estradiol injection?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
- swelling or tenderness in your stomach;
- jaundice (yellowing of the skin or eyes);
- memory problems, confusion, unusual behavior;
- unusual vaginal bleeding, pelvic pain;
- a lump in your breast; or
- high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.
Common side effects may include:
- breast pain;
- vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding;
- thinning scalp hair; or
- nausea, vomiting, bloating, stomach cramps.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about estradiol injection?
You should not use estradiol if you have: undiagnosed vaginal bleeding, liver disease, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia.
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What should I discuss with my health care provider before using estradiol injection?
You should not use estradiol if you are allergic to it, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a history of heart attack, stroke, or blood clot; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using estradiol can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
- heart disease;
- liver problems, or jaundice caused by pregnancy or taking hormones;
- a thyroid disorder;
- gallbladder disease;
- kidney disease;
- epilepsy or other seizure disorder;
- migraine headaches;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
- endometriosis or uterine fibroid tumors;
- high or low levels of calcium in your blood; or
- hereditary angioedema (an immune system disorder).
Using estradiol may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estradiol can slow breast milk production. Tell your doctor if you are breast-feeding.
How is estradiol injection given?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Estradiol is injected into a muscle, usually given once every 2 to 4 weeks, depending on the condition being treated. A healthcare provider can teach you how to properly use the medication by yourself.
Read and carefully follow any Instructions for Use provided with your medicine. Do not use estradiol if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.
Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk. Report any unusual vaginal bleeding right away.
If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estradiol.
Store at room temperature away from moisture and heat.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your estradiol injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using estradiol injection?
Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estradiol.
Grapefruit may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products.
What other drugs will affect estradiol injection?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may affect estradiol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Where can I get more information?
Your pharmacist can provide more information about estradiol injection.
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