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Dementia (cont.)

Dementia, Alzheimer's, and Aging BrainsĀ
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What are the risk factors for dementia?

The risk factors for developing dementia include age and family history. Age and a family history of dementia are non-modifiable risk factors. Abnormal genes which are associated with Alzheimer's disease have been identified, but are only rarely involved in the development of Alzheimer's disease. Conditions such as high blood pressure, high cholesterol, or diabetes increase the risks of developing either Alzheimer's disease or multi-infarct dementia. Some medications can lead to memory problems which look like dementia.

What is the treatment for dementia?

Treatment options for Alzheimer's disease and other dementias are limited. While there are medications available to try to improve the symptoms of Alzheimer's disease, the effect of these medications is limited. Physical exercise has been shown to be of some benefit in helping to maintain cognition. Staying engaged and participating in social events may also be of some help. To date, no treatment which can reverse the process of Alzheimer's disease has been identified.

Can dementia be prevented?

While there is no way to absolutely prevent the development of dementia, different activities have been identified which might decrease the risk. These include maintaining optimal health, including normal blood pressure, normal cholesterol, and normal blood sugars. Staying physically active, avoiding tobacco use or excess alcohol intake, maintaining a healthy weight, and preventing head injuries are also recommended.

What is the prognosis and life expectancy for someone with dementia?

Although Alzheimer's disease is listed as the 6th most common cause of death in the U.S., patients with Alzheimer's disease most commonly die due to infections caused by lack of mobility. Pneumonia, bladder infections, bedsores, and other causes can lead to more wide-spread infection and subsequent death. Patients with dementias have widely varying life expectancies, depending on the underlying cause of their dementia. Life expectancy can range from only 1 to 2 years to more than 15 years; the average duration of the disease is between 4 and 8 years after diagnosis.

What are the different types of dementia?

Alzheimer’s dementia/Alzheimer’s disease (AD) is the most common form of dementia. The cause has not yet been identified. While patients with AD have amyloid plaques (an accumulation of an abnormal protein) identified in certain areas of their brain, it is unclear if these plaques are the cause of the disease or a result of the disease. Although most cases of Alzheimer's disease begin after the age of 65, in some cases symptoms begin when someone is in their 40s or 50s. This early onset Alzheimer's disease can progress more rapidly than later onset AD.

Vascular dementia is the second most common cause of dementia, and is due to multiple strokes occuring within the brain. Often, these strokes may have been unnoticed and patients may not have any associated symptoms such as weakness, visual loss, or numbness. Patients with untreated high blood pressure or heart disease may be at risk of developing vascular dementia.

Frontotemporal dementia is associated with pronounced atrophy or shrinkage of the frontal and temporal lobes in the brain. In addition to forgetfulness and word finding problems, patients may have marked personality changes, impulsivity, or poor judgment. Some patients with frontotemporal dementia can develop incoordination or stiffness of their muscles.

Lewy body dementia/Lewy body disease is caused by Lewy bodies, which are abnormal clumps of certain proteins, accumulating inside of neurons. Forgetfulness and other signs of cognitive decline are the primary features of this condition, but patients can also develop prominent hallucinations which seem very real to them. Some patients with Lewy body disease develop symptoms which look like Parkinson's disease, such as tremor and slowness.

Creutzfeldt-Jakob disease is a rare condition where an abnormal protein leads to destruction of brain cells and dementia. While most cases occur without an underlying cause, in some patients there is a family history of this disorder. Even less often, patients might be exposed to the abnormal protein. Mad cow disease is one example of external exposure. This condition tends to progress rapidly, over only a few years, and is often associated with abnormal muscle movements.

Mixed dementia refers to patients who have evidence of two (or more) types of dementia. They are often described as having mixed dementia. Alzheimer's disease and vascular dementia are the most common causes of mixed dementia.

Normal pressure hydrocephalus is an abnormal enlargement of the ventricles, or fluid filled spaces within the brain, that causes pressure on areas of the brain. This leads to problems with walking, memory, and ability to control urine flow (incontinence). Although this can be identified with imaging of the brain (MRI or CT scan), further testing may be required to confirm the diagnosis. If diagnosed, this condition can be treated with placement of a shunt to drain the extra fluid.

Huntington’s disease causes characteristic abnormal movements, called chorea, in affected individuals. The movements are the hallmark of the diagnosis. However, in some cases, problems with memory can precede the development of the chorea by many years.

Alcoholic dementia is caused when patients drink heavily and develop deficiency in one of the B vitamins. When this happens, brain cells are unable to function normally and memory loss can occur. This is called Korsakoff syndrome. Although it is most commonly seen in alcoholics, patients who are malnourished from other causes are also at risk of developing this disorder.

Traumatic brain injury (concussion)/dementia pugilistica can lead to memory problems, as we have learned in recent years. In some cases, recurrent brain injuries or repeated concussions can contribute to the underlying changes identified in Alzheimer's disease.

Dementias caused by other conditions can lead to changes within the brain and associated cognitive decline. These include Parkinson's disease, HIV (AIDS), multiple sclerosis, Wilson's disease, meningitis (infection of the brain coverings), blood clots in the brain, and heart attacks. Some patients with brain tumors may develop memory problems which resemble dementia. Different medications can lead to some memory problems. Additionally, some patients with memory loss may take their medications incorrectly. It is important to note that not everyone that has been diagnosed with one of these conditions will develop dementia.

Delirium is a condition associated with confusion which comes on very rapidly and is associated with underlying illness or toxicity from alcohol or drugs. Withdrawal from certain medications or alcohol can also cause delirium. While in many cases delirium can be reversed, it's important to recognize the condition and obtain prompt treatment.

Dementia is rare in children, but individuals with Down Syndrome are at risk of developing dementia at an early age. Metabolic diseases such as Niemann-Pick disease, Lafora disease, or Batten disease can lead to dementia in children, but are typically associated with many other symptoms prior to the development of the memory problems.

How does one cope with being the caretaker of someone with dementia?

It is important for someone who is the primary caregiver of a patient with dementia to have a strong network of support. This is needed both to aid in caring for the patient and to give the caregiver some intermittent relief. In the early stages, many caregivers function more as a helper or guide, providing reminders for different tasks. Later in the disease, caregivers may have to supply basic care to the patient, including assistance with bathing, dressing, and going to the bathroom.

Obtaining power of attorney status for financial and medical matters and determining when a patient is no longer able to perform certain activities, such as driving, are difficult but necessary actions. Local Alzheimer's Association chapters are often helpful in completing these tasks. Enlisting the help of a patient's physician or mandating an on-the-road driving assessment can place the responsibility of determining when a patient is no longer safe to drive on someone other than a caregiver or family member, as driving is often an action that many patients attempt to perform far past the time when it is safe to continue. There are many sources of assistance for caregivers of patients with dementia:

Alzheimer's and Dementia Caregiver Center
Alzheimer's Association


Alzheimer’s Association.

"Leading Causes of Death." Centers for Disease Control and Prevention

Knopman, D. S., et al. "Report of the Quality Standards Subcommittee of the American Academy of Neurology." Neurology.56.9 (2001): 1143-1153.

Last Editorial Review: 3/3/2016


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