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Depo-Estradiol

Last reviewed on RxList: 11/9/2017
Depo-Estradiol Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 11/09/2017

Depo-Estradiol (estradiol cypionate) Injection is a form of estrogen used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Depo-Estradiol is also used to treat a lack of estrogen that is caused by ovarian failure or a condition called hypogonadism. Some forms of estradiol injection are used in men to treat the symptoms of prostate cancer. Depo-Estradiol is available in generic form. Common side effects of Depo-Estradiol include nausea, vomiting, loss of appetite, bloating, breast tenderness or swelling, headache, weight changes, acne or skin color changes, decreased sex drive, impotence, difficulty having an orgasm, migraine headaches, dizziness, vaginal pain/dryness/discomfort, swelling of your ankles or feet, depression, changes in your menstrual periods, or break-through bleeding.

The usual dosage range of Depo-Estradiol is 1 to 5 mg injected every 3 to 4 weeks. Depo-Estradiol may interact with St. John's wort, phenobarbital, blood thinners, ritonavir, carbamazepine, rifampin, or antibiotics. Tell your doctor all medications and supplements you use. Depo-Estradiol must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately. This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Our Depo-Estradiol (estradiol cypionate) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Depo-Estradiol Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • pain or swelling in your lower leg;
  • abnormal vaginal bleeding;
  • pain, swelling, or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes); or
  • a lump in your breast.

Less serious side effects may include:

  • nausea, vomiting, loss of appetite;
  • swollen breasts;
  • acne or skin color changes;
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • migraine headaches or dizziness;
  • vaginal pain, dryness, or discomfort;
  • swelling of your ankles or feet;
  • depression; or
  • changes in your menstrual periods, break-through bleeding.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Depo-Estradiol (Estradiol Cypionate Injection)

Depo-Estradiol Professional Information

SIDE EFFECTS

See Boxed Warnings, WARNINGS and PRECAUTIONS.

The following additional adverse reactions have been reported with estrogens and/or progestin therapy.

Genitourinary system

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting; dysmenorrhea; increase in size of uterine leiomyomata; vaginitis including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.

Breasts

Tenderness, enlargement pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.

Cardiovascular

Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.

Gastrointestinal

Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis, enlargement of hepatic hemangiomas.

Skin

Chloasma or melasma that may persist when drug is discontinued. Erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.

Eyes

Retinal vascular thrombosis; steepening of corneal curvature; intolerance to contact lenses.

Central nervous system

Headache, migraine, dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.

Miscellaneous

Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; changes in libido; arthralgias; leg cramps; anaphylactoid/anaphylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.

Drug Abuse And Dependence

Chlorobutanol anhydrous (chloral derivative) added as a preservative may be habit forming.

Read the entire FDA prescribing information for Depo-Estradiol (Estradiol Cypionate Injection)

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© Depo-Estradiol Patient Information is supplied by Cerner Multum, Inc. and Depo-Estradiol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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