Depo-Estradiol Side Effects Center

Last updated on RxList: 1/27/2022
Depo-Estradiol Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Depo-Estradiol?

Depo-Estradiol (estradiol cypionate) Injection is a form of estrogen used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Depo-Estradiol is also used to treat a lack of estrogen that is caused by ovarian failure or a condition called hypogonadism. Some forms of estradiol injection are used in men to treat the symptoms of prostate cancer. Depo-Estradiol is available in generic form.

What Are Side Effects of Depo-Estradiol?

Common side effects of Depo-Estradiol include:

  • nausea,
  • vomiting,
  • loss of appetite,
  • bloating,
  • breast tenderness or swelling,
  • headache,
  • weight changes,
  • acne or skin color changes,
  • decreased sex drive,
  • impotence,
  • difficulty having an orgasm,
  • migraine headaches,
  • dizziness,
  • vaginal pain/dryness/discomfort,
  • swelling of your ankles or feet,
  • depression,
  • changes in your menstrual periods, or
  • break-through bleeding

Dosage for Depo-Estradiol

The usual dosage range of Depo-Estradiol is 1 to 5 mg injected every 3 to 4 weeks.

What Drugs, Substances, or Supplements Interact with Depo-Estradiol?

Depo-Estradiol may interact with St. John's wort, phenobarbital, blood thinners, ritonavir, carbamazepine, rifampin, or antibiotics. Tell your doctor all medications and supplements you use.

Depo-Estradiol During Pregnancy or Breastfeeding

Depo-Estradiol must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately. This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Additional Information

Our Depo-Estradiol (estradiol cypionate) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer
Depo-Estradiol Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • swelling or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes);
  • memory problems, confusion, unusual behavior;
  • unusual vaginal bleeding, pelvic pain;
  • a lump in your breast; or
  • high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects may include:

  • breast pain;
  • headache;
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding;
  • thinning scalp hair; or
  • nausea, vomiting, bloating, stomach cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Depo-Estradiol (Estradiol Cypionate Injection)


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Depo-Estradiol Professional Information


See Boxed Warnings, WARNINGS and PRECAUTIONS.

The following additional adverse reactions have been reported with estrogens and/or progestin therapy.

Genitourinary system

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting; dysmenorrhea; increase in size of uterine leiomyomata; vaginitis including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.


Tenderness, enlargement pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.


Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.


Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis, enlargement of hepatic hemangiomas.


Chloasma or melasma that may persist when drug is discontinued. Erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.


Retinal vascular thrombosis; steepening of corneal curvature; intolerance to contact lenses.

Central nervous system

Headache, migraine, dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.


Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; changes in libido; arthralgias; leg cramps; anaphylactoid/anaphylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.

Drug Abuse And Dependence

Chlorobutanol anhydrous (chloral derivative) added as a preservative may be habit forming.

Read the entire FDA prescribing information for Depo-Estradiol (Estradiol Cypionate Injection)

© Depo-Estradiol Patient Information is supplied by Cerner Multum, Inc. and Depo-Estradiol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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