Depo-Medrol vs. Triamcinolone Cream

Are Depo-Medrol and Triamcinolone Cream the Same Thing?

Depo-Medrol (methylprednisolone acetate) and Triamcinolone acetonide cream are corticosteroids used to treat different conditions.

Depo-Medrol is used to treat pain and swelling that occurs with arthritis and other joint disorders. It may also be used to treat conditions such as blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/intestinal/kidney/lung diseases, and immune system disorders.

Triamcinolone acetonide cream is a topical medication prescribed to relieve skin inflammation, itching, dryness, and redness.

Side effects of Depo-Medrol and triamcinolone acetonide cream that are similar include acne.

Side effects of Depo-Medrol that are different from triamcinolone acetonide cream include nausea, vomiting, heartburn, headache, dizziness, trouble sleeping, appetite changes, increased sweating, or injection site reactions (pain, redness, swelling).

Side effects of triamcinolone acetonide cream that are different from Depo-Medrol include skin redness, burning, itching, irritation, excessive dryness, peeling, thinning skin, blistering skin, or stretch marks.

Depo-Medrol may interact with aldesleukin, mifepristone, antibiotics, other drugs that weaken the immune response, other drugs that cause bleeding/bruising, azole antifungals, boceprevir, cyclosporine, estrogens, HIV protease inhibitors, rifamycins, St. John's wort, seizure medications, and telaprevir.

Triamcinolone acetonide cream may interact with certain cancer chemotherapy agents and other topical medications.

What Are Possible Side Effects of Depo-Medrol?

Common side effects of Depo-Medrol include:

  • nausea,
  • vomiting,
  • heartburn,
  • headache,
  • dizziness,
  • trouble sleeping,
  • appetite changes,
  • increased sweating,
  • acne, or
  • injection site reactions (pain, redness, swelling).

Other side effects of Depo-Medrol include a rise in blood sugar, and a lowered ability to fight infections.

What Are Possible Side Effects of Triamcinolone Cream?

Common side effects of Triamcinolone Cream include:

  • skin redness,
  • burning,
  • itching,
  • irritation,
  • excessive dryness,
  • peeling,
  • thinning of your skin,
  • blistering skin,
  • stretch marks, and
  • acne.

Tell your doctor if you experience serious side effects of triamcinolone acetonide cream including:

  • blurred vision,
  • seeing halos around lights,
  • uneven heartbeats,
  • mood changes,
  • sleep problems (insomnia),
  • weight gain,
  • puffiness in your face, or
  • feeling tired.

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What Is Depo-Medrol?

Depo-Medrol (methylprednisolone acetate) is an anti-inflammatory glucocorticoid used to treat pain and swelling that occurs with arthritis and other joint disorders. It may also be used to treat conditions such as blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/intestinal/kidney/lung diseases, and immune system disorders. Depo-Medrol is available in generic form.

What Is Triamcinolone Cream?

Triamcinolone Acetonide (triamcinolone acetonide cream) is a topical corticosteroid prescribed to relieve skin inflammation, itching, dryness, and redness.

What Drugs Interact With Depo-Medrol?

Depo-Medrol may interact with aldesleukin, mifepristone, antibiotics, other drugs that weaken the immune response, other drugs that cause bleeding/bruising, azole antifungals, boceprevir, cyclosporine, estrogens, HIV protease inhibitors, rifamycins, St. John's wort, seizure medications, and telaprevir. Tell your doctor all medications and supplements you use. During pregnancy, Depo-Medrol should be used only when prescribed. It may rarely harm a fetus. Infants born to mothers who use this medication during pregnancy may have hormone problems. Tell your doctor if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

What Drugs Interact With Triamcinolone Cream?

Drug interactions may occur with certain cancer chemotherapy agents and other topical medications. Warnings may apply to individuals who have infections, certain eye conditions, circulatory disorders, or immune disorders. Triamcinolone Acetonide Cream is generally avoided during pregnancy and women who are breastfeeding. In cases where the benefits of treatment outweigh the risks, Triamcinolone Acetonide Cream may be used with extreme caution in pregnant or women who are breastfeeding. Caution is advised when using the drug in pediatric patients as they have a greater susceptibility to corticosteroid-induced hypothalamic-pituitary-adrenal (HPA) suppression and Cushing's syndrome.

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How Should Depo-Medrol Be Taken?

The initial dosage of Depo-Medrol varies from 4 to 120 mg depending on the disease being treated.

How Should Triamcinolone Cream Be Used?

Triamcinolone Acetonide Cream is available in 0.1% strengths in 15, 30 and 80 g tubes and is applied two to four times a day, depending on the doctor's prescription. After Triamcinolone Acetonide Cream is applied, the affected area should not be covered unless directed by a doctor.

Disclaimer

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The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

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References

FDA. Depo-Medrol Drug Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9a7b3837-e038-48bf-97e9-78ad463760dc
DailyMed. Triamcinolone Cream Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=51fedf94-d94e-42b7-8e9f-e0e9b6bbd055

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