Medical Editor: John P. Cunha, DO, FACOEP
DEPO -Testosterone (testosterone cypionate injection) is an androgen indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone including, 1) Primary hypogonadism (congenital or acquired) - testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy; and 2) Hypogonadotropic hypogonadism (congenital or acquired) - gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation. Common side effects of DEPO -Testosterone include:
- enlarged breasts in men
- prolonged erections
- excess hair growth
- male pattern of baldness
- skin rash
- water retention
- alterations in liver function tests
- increased or decreased sex drive
- numbness and tingling
- allergic reactions, and
- pain and inflammation at the injection site
The suggested dosage for DEPO-Testosterone Injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage of DEPO-Testosterone is adjusted according to the patient's response and the appearance of side effects. DEPO-Testosterone may interact with oral anticoagulants, oxyphenbutazone, and insulin. Tell your doctor all medications and supplements you use. DEPO -Testosterone is not recommended for use during pregnancy or while breastfeeding.
Our DEPO -Testosterone (testosterone cypionate injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- swelling, rapid weight gain;
- increased or ongoing erection of the penis;
- bone pain, increased thirst, memory problems, restless feeling, confusion, nausea, loss of appetite, increased urination, weakness, muscle twitching; or
- nausea, vomiting, stomach pain, loss of appetite, and jaundice (yellowing of the skin or eyes).
Women receiving testosterone injection may develop male characteristics, which could be irreversible if testosterone treatment is continued. Call your doctor as soon as possible if you notice any of these signs of excess testosterone:
- changes in your menstrual periods;
- male-pattern hair growth (such as on the chin or chest);
- male pattern baldness;
- enlarged clitoris; or
- increase or decrease in sex drive.
Less serious side effects may include:
- breast swelling in men;
- headache, anxiety, depressed mood;
- numbness or tingly feeling; or
- pain or swelling where the medicine was injected.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Depo-Testosterone (Testosterone Cypionate Injection)
The following adverse reactions in the male have occurred with some androgens:
Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.
Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.
Cardiovascular Disorders: myocardial infarction, stroke.
Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
Vascular disorders: Venous thromboembolism.
Miscellaneous: Inflammation and pain at the site of intramuscular injection.
Read the entire FDA prescribing information for Depo-Testosterone (Testosterone Cypionate Injection)