Last updated on RxList: 3/17/2021
DesOwen Side Effects Center

What Is DesOwen?

DesOwen (desonide) is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. DesOwen is available in generic form.

What Are Side Effects of DesOwen?

Common side effects of DesOwen include burning, stinging, itching, irritation, dryness, peeling, or redness when DesOwen is first applied to the skin. These side effects should disappear in a few days as your body adjusts to DesOwen. Other side effects of DesOwen include:

  • scaly skin,
  • thinning or softening of your skin,
  • skin rash or irritation around your mouth,
  • swollen hair follicles,
  • changes in color of treated skin,
  • blisters,
  • pimples,
  • crusting of treated skin, or
  • stretch marks.

Tell your doctor if you have signs of absorbing DesOwen through your skin including:

  • blurred vision, or seeing halos around lights,
  • mood changes,
  • sleep problems (insomnia),
  • weight gain,
  • puffiness in your face,
  • muscle weakness, or
  • feeling tired.

Dosage for DesOwen

DesOwen cream, ointment or lotion should be applied to the affected areas as a thin film two or three times daily depending on the severity of the condition. Shake lotion well before using.

What Drugs, Substances, or Supplements Interact with DesOwen?

It is not likely that other drugs you take orally or inject will have an effect on topically applied DesOwen. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications and supplements you are taking. Do not start a new medication without telling your doctor.

DesOwen During Pregnancy and Breastfeeding

DesOwen should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk when applied to the skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breastfeeding.

Additional Information

Our Brand DesOwen (desonide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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DesOwen Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Steroid medicine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • stinging or burning of treated skin;
  • skin irritation, redness, itching, or hardening;
  • dry, scaly, or oily skin;
  • swelling in your hands or feet;
  • acne, stretch marks; or
  • redness or crusting around your hair follicles.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for DesOwen (Desonide Cream, Ointment and Lotion)


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DesOwen Professional Information


In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%.

The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.


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Read the entire FDA prescribing information for DesOwen (Desonide Cream, Ointment and Lotion)

© DesOwen Patient Information is supplied by Cerner Multum, Inc. and DesOwen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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