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Desoxyn vs. Dexedrine Spansule, Zenzedi

Medical and Pharmacy Editor:

Are Desoxyn and Dexedrine Spansule the Same Thing?

Desoxyn (methamphetamine) and Dexedrine Spansule (dextroamphetamine sulfate) are central nervous system stimulants used to treat attention deficit hyperactivity disorder (ADHD).

Desoxyn is also used to treat obesity after other diets or medications have been tried without successful weight loss.

Dexedrine Spansule is also used to treat narcolepsy.

Side effects of Desoxyn and Dexedrine Spansule that are similar include headache, dizziness, sleep problems (insomnia), dry mouth, unpleasant taste in your mouth, diarrhea, constipation, loss of appetite, weight loss, loss of interest in sex, impotence, or difficulty having an orgasm.

Side effects of Dexedrine Spansule that are different from Desoxyn include nausea, stomach upset, cramps, nervousness, sweating, irritability, or restlessness.

Both Desoxyn and Dexedrine Spansule may interact with antidepressants, stomach acid medicine (including Alka-Seltzer or sodium bicarbonate), blood pressure medicines, or seizure medicines.

Desoxyn may also interact with insulin, cold medicines (decongestants), phenothiazines, or medications to treat mental illness.

Dexedrine Spansule may also interact with diuretics (water pills), antihistamines, acetazolamide, chlorpromazine, guanethidine, haloperidol, lithium, methenamine, or phenobarbital.

Withdrawal symptoms may occur if you suddenly stop taking Desoxyn or Dexedrine Spansule.

What Are Possible Side Effects of Desoxyn?

Common side effects of Desoxyn include:

  • headache,
  • dizziness,
  • sleep problems (insomnia),
  • dry mouth,
  • unpleasant taste in your mouth,
  • diarrhea,
  • constipation,
  • loss of appetite,
  • weight loss,
  • loss of interest in sex,
  • impotence, or
  • difficulty having an orgasm.

What Are Possible Side Effects of Dexedrine Spansule?

Common side effects of Dexedrine Spansule include:

  • nausea,
  • stomach upset,
  • cramps,
  • loss of appetite,
  • diarrhea,
  • constipation,
  • dry mouth or unpleasant taste in your mouth,
  • headache,
  • dizziness,
  • nervousness,
  • dizziness,
  • trouble sleeping (insomnia),
  • sweating,
  • weight loss,
  • irritability,
  • restlessness,
  • loss of interest in sex,
  • impotence, or
  • difficulty having an orgasm.

Tell your doctor if you have serious side effects of Dexedrine Spansule including:

  • numbness/pain/skin color change/sensitivity to temperature in the fingers or toes,
  • mental/mood/behavior changes (such as agitation, aggression, mood swings, depression, hallucinations, abnormal thoughts/behavior, thoughts of suicide),
  • uncontrolled movements,
  • muscle twitching or shaking,
  • outbursts of words or sounds,
  • swelling ankles or feet,
  • extreme tiredness,
  • significant unexplained weight loss, or
  • frequent or prolonged erections (in males).

What Is Desoxyn?

Desoxyn (methamphetamine) is a central nervous system stimulant that is used to treat attention deficit hyperactivity disorder (ADHD). Desoxyn is also used to treat obesity after other diets or medications have been tried without successful weight loss.

What Is Dexedrine Spansule?

Dexedrine Spansule and Zenzedi are central nervous system stimulants used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).

What Drugs Interact With Desoxyn?

Desoxyn may interact with insulin, cold medicines (decongestants), phenothiazines, or antidepressants. Tell your doctor all medications and supplements you use. Metamphetamine may be harmful to an unborn baby. It could also cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes methamphetamine during pregnancy. Methamphetamine can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Methamphetamine is a drug of abuse and can be habit-forming.

What Drugs Interact With Dexedrine Spansule?

Dexedrine Spansule, Zenzedi may interact blood pressure medications, diuretics (water pills), antihistamines, acetazolamide, chlorpromazine, ethosuximide, guanethidine, haloperidol, lithium, methenamine, phenytoin, phenobarbital, sodium bicarbonate (Alka-Seltzer), or antidepressants. Tell your doctor all medications you are taking. Dexedrine should be used only if prescribed during pregnancy. Infants born to mothers who are dependent on this medication may be born too soon (premature) and have low birth weight. They may also have withdrawal symptoms. Tell your doctor if you notice mood changes, agitation, or unusual tiredness in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding is not recommended. Dexedrine may be habit-forming. Withdrawal symptoms may occur after stopping this drug.

How Should Desoxyn Be Taken?

For treatment of children 6 years or older with a behavioral syndrome characterized by moderate to severe distractibility, short attention span, hyperactivity, emotional lability and impulsivity, an initial dose of 5 mg Desoxyn once or twice a day is recommended. To treat obesity in adults, one 5 mg tablet of Desoxyn should be taken one-half hour before each meal.

How Should Dexedrine Spansule Be Taken?

The usual dose of Dexedrine Spansule, Zenzedi to treat narcolepsy is 5 to 60 mg per day in divided doses, depending on the patient response. For treatment of ADHD in pediatric patients 6 years of age and older, start with 5 mg once or twice daily; daily dosage may be raised by a physician.

Reviewed on 2/14/2019

References:
Dailymed. Desoxyn Drug Information.
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f03a68d5-ed00-8a2d-af68-28be909ea85f&type=display
FDA. Dexedrine Drug Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017078s042lbl.pdf

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