Desoxyn vs. Vyvanse

Are Desoxyn and Vyvanse the Same Thing?

Desoxyn (methamphetamine) and Vyvanse (lisdexamfetamine dimesylate) are central nervous system stimulants used to treat attention deficit hyperactivity disorder (ADHD).

Desoxyn is also used to treat obesity after other diets or medications have been tried without successful weight loss.

Vyvanse is also used to treat moderate to severe binge eating disorder.

Side effects of Desoxyn and Vyvanse that are similar include headache, dizziness, sleep problems (insomnia), dry mouth, unpleasant taste in your mouth, diarrhea, constipation, loss of appetite, or weight loss.

Side effects of Desoxyn that are different from Vyvanse include loss of interest in sex, impotence, or difficulty having an orgasm.

Side effects of Vyvanse that are different from Desoxyn include anxiety, irritability, nausea, abdominal or stomach pain, vomiting, increased heart rate, jittery feeling, mild skin rash, nervousness, sweating, and restlessness.

Both Desoxyn and Vyvanse may interact with blood pressure medicines, antidepressants, or seizure medicines.

Desoxyn may also interact with insulin, cold medicines (decongestants), phenothiazines, stomach acid medicine (including Alka-Seltzer or sodium bicarbonate), or medications to treat mental illness.

Vyvanse may also interact with ammonium chloride, ascorbic acid (vitamin C), K-Phos, diuretics (water pills), antihistamines, chlorpromazine, lithium, methenamine, phenobarbital, or pain medications.

Withdrawal symptoms may occur if you suddenly stop taking Desoxyn or Vyvanse.

What Are Possible Side Effects of Desoxyn?

Common side effects of Desoxyn include:

  • headache,
  • dizziness,
  • sleep problems (insomnia),
  • dry mouth,
  • unpleasant taste in your mouth,
  • diarrhea,
  • constipation,
  • loss of appetite,
  • weight loss,
  • loss of interest in sex,
  • impotence, or
  • difficulty having an orgasm.

What Are Possible Side Effects of Vyvanse?

Vyvanse may cause serious side effects, including:

  • slowing of growth (height and weight) in children

The most common side effects of Vyvanse in ADHD include:

  • anxiety
  • decreased appetite
  • diarrhea
  • dizziness
  • dry mouth
  • irritability
  • loss of appetite
  • nausea
  • trouble sleeping
  • upper stomach pain
  • vomiting
  • weight loss

The most common side effects of Vyvanse in BED include:

  • dry mouth
  • trouble sleeping
  • decreased appetite
  • increased heart rate
  • constipation
  • feeling jittery
  • anxiety

Talk to your doctor if you have any side effects that bother you or do not go away.

These are not all the possible side effects of Vyvanse. For more information ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What Is Desoxyn?

Desoxyn (methamphetamine) is a central nervous system stimulant that is used to treat attention deficit hyperactivity disorder (ADHD). Desoxyn is also used to treat obesity after other diets or medications have been tried without successful weight loss.

What Is Vyvanse?

Vyvanse is a central nervous system stimulant prescription medicine used to treat:

  • Attention-Deficit/Hyperactivity Disorder (ADHD). Vyvanse may help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD
  • Binge Eating Disorder (BED). Vyvanse may help reduce the number of binge eating days in patients with BED

Vyvanse is not for weight loss. It is not known if Vyvanse is safe and effective for the treatment of obesity.

It is not known if Vyvanse is safe and effective in children with ADHD under 6 years of age or in patients with BED under 18 years of age.

Do not take Vyvanse if you:

  • are taking or have taken within the past 14 days an anti-depression medicine called a monoamine oxidase inhibitor or MAOI
  • are sensitive to, allergic to, or had a reaction to other stimulant medicines

Before you take Vyvanse, tell your doctor if you have or if there is a family history of:

Tell your doctor if:

  • You have any kidney problems. Your doctor may lower your dose.
  • You are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby
  • You are breastfeeding or plan to breastfeed. Vyvanse can pass into your milk. Do not breastfeed while taking Vyvanse. Talk to your doctor about the best way to feed your baby if you take Vyvanse.

What Drugs Interact With Desoxyn?

Desoxyn may interact with insulin, cold medicines (decongestants), phenothiazines, or antidepressants. Tell your doctor all medications and supplements you use. Metamphetamine may be harmful to an unborn baby. It could also cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes methamphetamine during pregnancy. Methamphetamine can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Methamphetamine is a drug of abuse and can be habit-forming.

What Drugs Interact With Vyvanse?

Tell your doctor about all of the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Vyvanse can affect the way other medicines work, and other medicines may affect how Vyvanse works. Using Vyvanse with other medicines can cause serious side effects.

Especially tell your doctor if you take anti-depression medicines including MAOIs.

Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Know the medicines that you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

Do not start any new medicine while taking Vyvanse without talking to your doctor first.

Do not drive, operate machinery, or do other dangerous activities until you know how Vyvanse affects you

How Should Desoxyn Be Taken?

For treatment of children 6 years or older with a behavioral syndrome characterized by moderate to severe distractibility, short attention span, hyperactivity, emotional lability and impulsivity, an initial dose of 5 mg Desoxyn once or twice a day is recommended. To treat obesity in adults, one 5 mg tablet of Desoxyn should be taken one-half hour before each meal.

How Should Vyvanse Be Taken?

  • Take Vyvanse exactly as your doctor tells you to take it.
  • Your doctor may change your dose until it is right for you.
  • Take Vyvanse 1 time each day in the morning.
  • Vyvanse can be taken with or without food.
  • Vyvanse capsules may be swallowed whole.
  • If you have trouble swallowing capsules, open your Vyvanse capsule and pour all the powder into yogurt, water, or orange juice.
    • Use all of the Vyvanse powder from the capsule so you get all of the medicine.
    • Using a spoon, break apart any powder that is stuck together. Stir the Vyvanse powder and yogurt, water or orange juice until they are completely mixed together.
    • Eat all the yogurt or drink all the water or orange juice right away after it has been mixed with Vyvanse. Do not store the yogurt, water, or orange juice after it has been mixed with Vyvanse. It is normal to see a film y coating on the inside of your glass or container after you eat or drink all the Vyvanse.
  • Your doctor may sometimes stop Vyvanse treatment for a while to check your ADHD or your BED symptoms.
  • Your doctor may do regular checks of your heart, and blood pressure while taking Vyvanse.
  • Children should have their height and weight checked often while taking Vyvanse. Vyvanse treatment may be stopped if a problem.
  • If you take too much Vyvanse, call your doctor or poison control center (1-800-222-1222) right away, or get to the nearest hospital emergency room.

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You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


Dailymed. Desoxyn Drug Information.
Shire Pharmaceuticals. Vyvanse Drug Information.

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