Desyrel (trazodone) vs. Seroquel

Are Desyrel and Seroquel the Same Thing?

Desyrel (trazodone hydrochloride) and Seroquel (quetiapine) are used to treat depression.

Seroquel is also used to treat schizophrenia in adults and children who are at least 13 years old and bipolar disorder.

Desyrel and Seroquel belong to different drug classes. Desyrel is a phenylpiperazine antidepressant and Seroquel is a psychotropic medication.

The brand name Desyrel is no longer available in the U.S. but may be available in generic form.

Side effects of Desyrel and Seroquel that are similar include nausea, vomiting, drowsiness, dizziness, tiredness, changes in weight, headache, dry mouth, and constipation.

Side effects of Desyrel that are different from Seroquel include diarrhea, blurred vision, muscle ache/pain, bad taste in the mouth, stuffy nose, and changes in sexual interest/ability.

Side effects of Seroquel that are different from Desyrel include mood or behavior changes, stomach pain, upset stomach, lightheadedness, trouble sleeping, sore throat, breast swelling or discharge, missed menstrual periods, and increased appetite.

Both Desyrel and Seroquel may interact with HIV medicines and antifungal medications.

Desyrel may also interact with digoxin, seizure medicines, warfarin, and monoamine oxidase inhibitors (MAOIs).

Seroquel may also interact with antidepressants, steroids, cimetidine, thioridazine, lorazepam, other medicines for infections, asthma, heart problems, high blood pressure, mental illness, cancer, or malaria.

What Are Possible Side Effects of Desyrel?

Common side effects of Desyrel (trazadone) include:

  • nausea,
  • vomiting,
  • diarrhea,
  • drowsiness,
  • dizziness,
  • tiredness,
  • blurred vision,
  • changes in weight,
  • headache,
  • muscle ache/pain,
  • dry mouth,
  • bad taste in the mouth,
  • stuffy nose,
  • constipation, or
  • change in sexual interest/ability.

What Are Possible Side Effects of Seroquel?

Common side effects of Seroquel include:

  • mood or behavior changes,
  • constipation,
  • stomach pain,
  • upset stomach,
  • nausea,
  • vomiting,
  • drowsiness,
  • dizziness,
  • lightheadedness,
  • tiredness,
  • headache,
  • trouble sleeping,
  • dry mouth,
  • sore throat,
  • breast swelling or discharge,
  • missed menstrual periods,
  • increased appetite, or
  • weight gain.

What is Desyrel?

Desyrel (trazodone hydrochloride) is an antidepressant used to treat depression. The brand name Desyrel is no longer available in the U.S. but may be available in generic form.

What is Seroquel?

Seroquel (quetiapine) is a psychotropic medication used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel is also used in the treatment of major depression and bipolar disorder.

What Drugs Interact With Desyrel?

Desyrel (trazadone) may interact with HIV medicines, antifungal medications, digoxin, seizure medicines, warfarin, or MAO inhibitors. Tell your doctor all medications you use. During pregnancy, trazodone should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Seroquel?

Seroquel may interact with other drugs that make you sleepy (cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety), heart or blood pressure medications, antibiotics, antidepressants, antifungal medications, HIV/AIDS medicines, migraine headache medicines, or seizure medications.

Seroquel may also interact with medications to treat Parkinson's disease, steroids, anti-malaria medications, heart rhythm medicines, and other medicines to treat psychiatric disorders.

How Should Desyrel be Taken?

The initial adult dose of Desyrel (trazodone) is 150 mg/day in divided doses. The dose may be increased by 50 mg/day every three to four days. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses.

How Should Seroquel Be Taken?

Dosing preparations are 25, 50, 100, 200, 300, and 400 mg tablets.

Seroquel may be taken with or without food.

If you miss a dose of Seroquel, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Seroquel at the same time.

If you take too much Seroquel, call your healthcare provider or poison control center right away, or get emergency treatment.


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Mead Johnson Pharmaceutical. Desyrel Product Information.

AstraZeneca. Seroquel Product Information.

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