Desyrel (trazodone) vs. Seroquel

Reviewed on 5/12/2020

Are Desyrel and Seroquel the Same Thing?

Desyrel (trazodone hydrochloride) and Seroquel (quetiapine) are used to treat depression.

Seroquel is also used to treat schizophrenia in adults and children who are at least 13 years old and bipolar disorder.

Desyrel and Seroquel belong to different drug classes. Desyrel is a phenylpiperazine antidepressant and Seroquel is a psychotropic medication.

The brand name Desyrel is no longer available in the U.S. but may be available in generic form.

Side effects of Desyrel and Seroquel that are similar include nausea, vomiting, drowsiness, dizziness, tiredness, changes in weight, headache, dry mouth, and constipation.

Side effects of Desyrel that are different from Seroquel include diarrhea, blurred vision, muscle ache/pain, bad taste in the mouth, stuffy nose, and changes in sexual interest/ability.

Side effects of Seroquel that are different from Desyrel include mood or behavior changes, stomach pain, upset stomach, lightheadedness, trouble sleeping, sore throat, breast swelling or discharge, missed menstrual periods, and increased appetite.

Both Desyrel and Seroquel may interact with HIV medicines and antifungal medications.

Desyrel may also interact with digoxin, seizure medicines, warfarin, and monoamine oxidase inhibitors (MAOIs).

Seroquel may also interact with antidepressants, steroids, cimetidine, thioridazine, lorazepam, other medicines for infections, asthma, heart problems, high blood pressure, mental illness, cancer, or malaria.

What Are Possible Side Effects of Desyrel?

Common side effects of Desyrel (trazadone) include:

  • nausea,
  • vomiting,
  • diarrhea,
  • drowsiness,
  • dizziness,
  • tiredness,
  • blurred vision,
  • changes in weight,
  • headache,
  • muscle ache/pain,
  • dry mouth,
  • bad taste in the mouth,
  • stuffy nose,
  • constipation, or
  • change in sexual interest/ability.

What Are Possible Side Effects of Seroquel?

Common side effects of Seroquel include:

  • mood or behavior changes,
  • constipation,
  • stomach pain,
  • upset stomach,
  • nausea,
  • vomiting,
  • drowsiness,
  • dizziness,
  • lightheadedness,
  • tiredness,
  • headache,
  • trouble sleeping,
  • dry mouth,
  • sore throat,
  • breast swelling or discharge,
  • missed menstrual periods,
  • increased appetite, or
  • weight gain.

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow

What is Desyrel?

Desyrel (trazodone hydrochloride) is an antidepressant used to treat depression. The brand name Desyrel is no longer available in the U.S. but may be available in generic form.

What is Seroquel?

Seroquel (quetiapine) is a psychotropic medication used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel is also used in the treatment of major depression and bipolar disorder.

What Drugs Interact With Desyrel?

Desyrel (trazadone) may interact with HIV medicines, antifungal medications, digoxin, seizure medicines, warfarin, or MAO inhibitors. Tell your doctor all medications you use. During pregnancy, trazodone should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Seroquel?

Seroquel may interact with other drugs that make you sleepy (cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety), heart or blood pressure medications, antibiotics, antidepressants, antifungal medications, HIV/AIDS medicines, migraine headache medicines, or seizure medications.

Seroquel may also interact with medications to treat Parkinson's disease, steroids, anti-malaria medications, heart rhythm medicines, and other medicines to treat psychiatric disorders.

How Should Desyrel be Taken?

The initial adult dose of Desyrel (trazodone) is 150 mg/day in divided doses. The dose may be increased by 50 mg/day every three to four days. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses.

How Should Seroquel Be Taken?

Dosing preparations are 25, 50, 100, 200, 300, and 400 mg tablets.

Seroquel may be taken with or without food.

If you miss a dose of Seroquel, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Seroquel at the same time.

If you take too much Seroquel, call your healthcare provider or poison control center right away, or get emergency treatment.

QUESTION

Depression is a(n) __________ . See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Mead Johnson Pharmaceutical. Desyrel Product Information.

http://www.mentalmeds.org/prescription_meds/Desyrel.pdf

AstraZeneca. Seroquel Product Information.

https://www.seroquelxr.com/

Health Solutions From Our Sponsors