Detectnet Side Effects Center

Last updated on RxList: 1/7/2022
Detectnet Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Detectnet?

Detectnet (copper cu 64 dotatate injection, solution) is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients

What Are Side Effects of Detectnet?

Side effects of include:

Dosage for Detectnet

The recommended dose of Detectnet is 148 MBq (4 mCi) administered as an intravenous bolus injection.

Detectnet In Children

The safety and effectiveness of Detectnet have not been established in pediatric patients.

What Drugs, Substances, or Supplements Interact with Detectnet?

Detectnet may interact with other medicines such as:

  • somatostatin analogs

Tell your doctor all medications and supplements you use.

Detectnet During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Detectnet; all radiopharmaceuticals, including Detectnet have the potential to cause fetal harm depending on the fetal stage of development and the magnitude of the radiation dose. It is unknown if Detectnet passes into breast milk. Breastfeeding should be interrupted for 12 hours after Detectnet administration in order to minimize radiation exposure to a breastfed infant.

Additional Information

Our Detectnet (copper cu 64 dotatate injection, solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Detectnet Professional Information

SIDE EFFECTS

The following clinically significant adverse reactions are described elsewhere in the labeling:

  • Hypersensitivity reactions [see WARNINGS AND PRECAUTIONS]

Clinical Trial Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In safety and efficacy trials, 71 subjects received a single dose of Detectnet. Of these 71 subjects, 21 were healthy volunteers and the remainder were patients with known or suspected NET.

The following adverse reactions occurred at a rate of < 2%:

  • Gastrointestinal Disorders: nausea, vomiting
  • Vascular Disorders: flushing

In published clinical experience, 126 patients with known history of NET received a single dose of copper Cu 64 dotatate injection. Four patients were reported to have experienced nausea immediately after injection.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of other somatostatin receptor imaging agents. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to the drug.

Immune System Disorders: Hypersensitivity reactions, predominantly rash, pruritus, less frequently angioedema or features of anaphylaxis

DRUG INTERACTIONS

Somatostatin Analogs

Non-radioactive somatostatin analogs and copper Cu 64 dotatate competitively bind to somatostatin receptors (SSTR2). Image patients just prior to dosing with somatostatin analogs. For patients on longacting somatostatin analogs, a wash-out period of 28 days is recommended prior to imaging. For patients on short-acting somatostatin analogs, a washout period of 2 days is recommended prior to imaging [see DOSAGE AND ADMINISTRATION].

Read the entire FDA prescribing information for Detectnet (Copper Cu 64 dotatate Injection, for Intravenous Use)

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© Detectnet Patient Information is supplied by Cerner Multum, Inc. and Detectnet Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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