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Last reviewed on RxList: 10/20/2017
Dexferrum Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/20/2017

Dexferrum (iron dextran injection) is a form of the mineral iron indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Common side effects of Dexferrum include allergic reactions (including anaphylaxis), chest pain/tightness, hives, abdominal pain, increased white blood cell count (leukocytosis), joint pain, convulsions, respiratory arrest, blood in the urine, fever, nausea, vomiting, arrhythmias, and bronchospasm.

The dose of Dexferrum is based on the patient's lean body weight, the target hemoglobin (Hgb) desired, and whether the iron replacement is due to anemia or blood loss. Dexferrum may interact with angiotensin-converting enzyme (ACE) inhibitors. Tell your doctor all medications and supplements you use. During pregnancy, Dexferrum should only be used if prescribed. Tell your doctor if you are pregnant or become pregnant while taking Dexferrum. Dexferrum passes into breast milk. Consult your doctor before breastfeeding.

Our Dexferrum (iron dextran injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Dexferrum Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Iron dextran can cause severe and sometimes fatal allergic reactions or severely low blood pressure. Tell your caregiver right away if you feel light-headed or if you suddenly have trouble breathing.

Call your doctor at once if you have:

  • fast or slow heartbeats. chest pain, wheezing, trouble breathing;
  • a light-headed feeling, like you might pass out;
  • flushing (warmth, redness, or tingly feeling);
  • blue-colored lips or fingernails;
  • red or pink urine;
  • weak or shallow breathing (breathing may stop);
  • seizure (convulsions);
  • swelling, warmth, redness, or itching where the medicine was injected; or
  • delayed effect (1-2 days after injection)--fever, chills, dizziness, headache, general ill feeling, nausea and vomiting, joint or muscle pain, back pain.

Common side effects may include:

  • mild itching or rash;
  • body aches, numbness or tingly feeling;
  • nausea, vomiting, stomach pain, diarrhea;
  • mild dizziness or weakness, low fever; or
  • brown discoloration of your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dexferrum (Iron Dextran Injection, USP)


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Dexferrum Professional Information


Severe/Fatal: Anaphylactic reactions have been reported with the use of iron dextran injection; on occasions these reactions have been fatal. Such reactions, which occur most often within the first several minutes of administration, have been generally characterized by sudden onset of respiratory difficulty and/or cardiovascular collapse. Because fatal anaphylactic reactions have been reported after administration of iron dextran injection, the drug should be given only when resuscitation techniques and treatment of anaphylactic and anaphylactoid shock are readily available. (See BOXED WARNING and PRECAUTIONS: General, pertaining to immediate availability of epinephrine.)

Cardiovascular: Chest pain, chest tightness, shock, cardiac arrest, hypotension, hypertension, tachycardia, bradycardia, flushing, arrhythmias. (Flushing and hypotension may occur from too rapid injections by the intravenous route.)

Dermatologic: Urticaria, pruritus, purpura, rash, cyanosis.

Gastrointestinal: Abdominal pain, nausea, vomiting, diarrhea.

Hematologic/lymphatic: Leucocytosis, lymphadenopathy.

Musculoskeletal/soft tissue: Arthralgia, arthritis (may represent reactivation in patients with quiescent rheumatoid arthritis -See PRECAUTIONS: General), myalgia; backache; sterile abscess; brown skin and/or underlying tissue discoloration (staining); cellulitis; swelling; inflammation; local phlebitis at or near intravenous injection site.

Neurologic: Convulsions, seizures, syncope, headache, weakness, unresponsiveness, paresthesia, febrile episodes, chills, dizziness, disorientation, numbness, unconsciousness.

Res piratory: Respiratory arrest, dyspnea, bronchospasm, wheezing.

Urologic: Hematuria.

Delayed reactions : Arthralgia, backache, chills, dizziness, fever, headache, malaise, myalgia, nausea, vomiting (See WARNINGS).

Miscellaneous : Febrile episodes, sweating, shivering, chills, malaise, altered taste.

Read the entire FDA prescribing information for Dexferrum (Iron Dextran Injection, USP)

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© Dexferrum Patient Information is supplied by Cerner Multum, Inc. and Dexferrum Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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