DHE 45 Side Effects Center

Last updated on RxList: 7/12/2021
DHE 45 Side Effects Center

What Is D.H.E. 45?

D.H.E. 45 (dihydroergotamine mesylate) is an ergot alkaloid used to treat a migraine or cluster headache attack. D.H.E. 45 will only treat a headache that has already begun and will not prevent headaches or reduce the number of attacks. D.H.E. 45 is available in generic form.

What Are Side Effects of D.H.E. 45?

Common side effects of D.H.E. 45 include:

    dizziness, drowsiness, headache, nausea, vomiting, diarrhea, flushing (redness or tingly feeling under the skin), increased sweating, anxiety, or skin rash. Tell your doctor if you experience serious side effects of D.H.E. 45 including slow/fast/irregular heartbeat, tingling/pain/coldness in the fingers or toes, whitish fingers/toes/nails, loss of feeling in the fingers or toes, bluish hands or feet, muscle pain or weakness in the arms or legs, severe stomach or abdominal pain, lower back pain, or little or no urine.

    Dosage for D.H.E. 45

    D.H.E. 45 Injection is administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. The total weekly dosage should not exceed 6 mL.

    What Drugs, Substances, or Supplements Interact with D.H.E. 45?

    D.H.E. 45 may interact with other migraine headache medicines, zileuton, cold or allergy medications, nicotine, diet pills, stimulants, medication to treat ADHD, antidepressants, antifungal medications, or heart or blood pressure medication. Tell your doctor all medications you use.

    D.H.E. 45 During Pregnancy or Breastfeeding

    D.H.E. 45 may harm a fetus and must not be used during pregnancy. Men and women should use 2 forms of birth control (e.g., condoms, birth control pill) while using this medication. Consult your doctor to discuss birth control. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Breastfeeding is not recommended while using this drug.

    Additional Information

    Our D.H.E. 45 (dihydroergotamine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Who suffers more frequently from migraine headaches? See Answer
DHE 45 Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • numbness or tingling in your fingers or toes;
  • muscle pain in your arms or legs;
  • leg weakness;
  • fast or slow heartbeats;
  • chest pain or tightness, shortness of breath;
  • swelling or itching;
  • stomach cramps, diarrhea that may be bloody;
  • severe headache; or
  • discoloration or skin changes in your hands or feet.

Common side effects may include:

  • headache, dizziness, anxiety;
  • diarrhea;
  • numbness, tingling, burning pain;
  • increased blood pressure;
  • rash, increased sweating; or
  • flushing (sudden warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for DHE 45 (Dihydroergotamine)


16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow
DHE 45 Professional Information


Serious cardiac events, including some that have been fatal, have occurred following use of D.H.E. 45® (dihydroergotamine mesylate) Injection, USP, but are extremely rare. Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation. ( See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS)

Post-Introduction Reports

The following events derive from postmarketing experience have been occasionally reported in patients receiving D.H.E. 45® (dihydroergotamine mesylate) Injection, USP vasospasm, paraesthesia, hypertension, dizziness, anxiety, dyspnea, headache, flushing, diarrhea, rash, increased sweating, and pleural and retroperitoneal fibrosis after long-term use of dihydroergotamine. Extremely rare cases of myocardial infarction and stroke have been reported. A causal relationship has not been established. D.H.E. 45® (dihydroergotamine mesylate) Injection, USP is not recommended for prolonged daily use. (See DOSAGE AND ADMINISTRATION)


Currently available data have not demonstrated drug abuse or psychological dependence with dihydroergotamine. However, cases of drug abuse and psychological dependence in patients on other forms of ergot therapy have been reported. That, due to the chronicity of vascular headaches, it is imperative that patients be advised not to exceed recommended dosages.

Read the entire FDA prescribing information for DHE 45 (Dihydroergotamine)

© DHE 45 Patient Information is supplied by Cerner Multum, Inc. and DHE 45 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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