Medical Author: John P. Cunha, DO, FACOEP Last updated on RxList: 1/6/2022
Diabinese Side Effects Center

What Is Diabinese?

Diabinese (chlorpropamide) is an oral diabetes medicine used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used with Diabinese if needed. Diabinese is available in generic form.

What Are Side Effects of Diabinese?

Common side effects of Diabinese include:

The most common side effect of Diabinese is low blood sugar (hypoglycemia). Tell your doctor if you experience symptoms of low blood sugar including headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Tell your doctor if you have serious side effects of Diabinese including:

  • skin changes (such as darkening, thickening),
  • unusual fatigue,
  • fast or pounding heartbeat,
  • easy bruising or bleeding,
  • mental/mood changes,
  • sudden weight gain,
  • swelling of the hands or feet,
  • muscle weakness or spasm,
  • painful bowel movements,
  • bloody or black stools,
  • yellowing eyes or skin,
  • persistent nausea or vomiting,
  • severe stomach or abdominal pain,
  • dark urine,
  • signs of infection (such as fever, persistent sore throat), or
  • seizures.

Dosage for Diabinese

The initial dosage range for Diabinese for mild to moderately severe, middle-aged, stable type 2 diabetes patients is 250 mg daily.

What Drugs, Substances, or Supplements Interact with Diabinese?

High blood sugar (hyperglycemia) may result if you take Diabinese with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, diet pills, medicines to treat asthma, colds or allergies. Low blood sugar (hypoglycemia) may result if you take Diabinese with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, probenecid, or blood thinners. Tell your doctor all medications you use.

Diabinese During Pregnancy or Breastfeeding

Diabinese should be used only when prescribed during pregnancy. It is not recommended for use for at least 1 month before delivery because it may cause low blood sugar in newborns. Your doctor may substitute insulin during your pregnancy. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Diabinese (chlorpropamide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Type 2 Diabetes: Signs, Symptoms, Treatments See Slideshow
Diabinese Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • dark urine, jaundice (yellowing of the skin or eyes);
  • severe skin rash, redness, or itching;
  • pale skin, easy bruising or bleeding;
  • fever, chills, sore throat, mouth sores; or
  • low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Older adults may be more likely to have low blood sugar while taking this medicine.

Common side effects may include:

  • nausea;
  • heartburn; or
  • full feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Diabinese (Chlorpropamide)


______________ is another term for type 2 diabetes. See Answer
Diabinese Professional Information


Body as a Whole: Disulfiram-like reactions have rarely been reported with DIABINESE (chlorpropamide) (see DRUG INTERACTIONS).

Central and Peripheral Nervous System: Dizziness and headache.

Hypoglycemia: See PRECAUTIONS and OVERDOSAGE sections.

Gastrointestinal: Gastrointestinal disturbances are the most common reactions; nausea has been reported in less than 5% of patients, and diarrhea, vomiting, anorexia, and hunger in less than 2%. Other gastrointestinal disturbances have occurred in less than 1% of patients including proctocolitis. They tend to be dose-related and may disappear when dosage is reduced.

Liver/Biliary: Cholestatic jaundice and hepatitis may occur rarely, which may progress to liver failure; DIABINESE (chlorpropamide) should be discontinued if this occurs. Hepatic porphyria and disulfiram-like reactions have been reported with DIABINESE (chlorpropamide) .

Skin/Appendages: Pruritus has been reported in less than 3% of patients. Other allergic skin reactions, e.g., urticaria and maculopapular eruptions have been reported in approximately 1% or less of patients. These may be transient and may disappear despite continued use of DIABINESE (chlorpropamide) ; if skin reactions persist the drug should be discontinued.

As with other sulfonylureas, porphyria cutanea tarda and photosensitivity reactions have been reported.

Skin eruptions rarely progressing to erythema multiforme and exfoliative dermatitis have also been reported.

Hematologic Reactions: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia (see PRECAUTIONS), aplastic anemia, pancytopenia, and eosinophilia have been reported with sulfonylureas.

Metabolic/Nutritional Reactions: Hypoglycemia (see PRECAUTIONS and OVERDOSAGE sections). Hepatic porphyria and disulfiram-like reactions have been reported with DIABINESE (chlorpropamide) . See DRUG INTERACTIONS section.

Endocrine Reactions: On rare occasions, chlorpropamide has caused a reaction identical to the syndrome of inappropriate antidiuretic hormone (ADH) secretion. The features of this syndrome result from excessive water retention and include hyponatremia, low serum osmolality, and high urine osmolality. This reaction has also been reported for other sulfonylureas.

Read the entire FDA prescribing information for Diabinese (Chlorpropamide)

© Diabinese Patient Information is supplied by Cerner Multum, Inc. and Diabinese Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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