1,2-diglyceride, 1,3-diglyceride, DAG, Diacilglicerol, Diacylglycérol, Diacylglycerol Oil, Diglyceride, Diglycéride, Huile de Diacylglycérol.
Diacylglycerol is found in small amounts in plant oils. In its concentrated form, it is used to replace fats in the diet.
Diacylglycerol is used to promote weight loss and to treat high levels of certain blood fats called triglycerides.
In manufacturing, diacylglycerol is used as a stabilizer, thickener, and texturizer.
How does it work?
Diacylglycerol might work by increasing energy use and the breakdown of fat.
Possibly Effective for...
- Weight loss and reduction of body fat. Diacylglycerol, when used in place of other fats, might promote modest weight loss. Diacylglycerol is generally added to products such as muffins, crackers, soup, cookies, and granola bars.
Insufficient Evidence to Rate Effectiveness for...
- Type 2 diabetes. Some research suggests that diacylglycerol might lower blood sugar and blood fats called triglycerides in people who have type 2 diabetes. There is also some evidence that diacylglycerol might also slow progression of kidney failure in people with type 2 diabetes, possibly by reducing triglycerides.
- High blood levels of triglycerides.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Diacylglycerol appears to be safe for most people. It can cause digestive tract upset, headache, acne, and rash.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of diacylglycerol during pregnancy and breast-feeding. Stay on the safe side and avoid use.
The following doses have been studied in scientific research:
- For weight loss and reducing body fat: 10 to 45 grams of diacylglycerol per day in foods in place of other fats. Generally, each serving contains 8 to 9 grams of diacylglycerol oil, used in place of other dietary fats, in 2 to 5 servings per day.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Health Solutions From Our Sponsors
Maki KC, Davidson MH, Tsushima R, et al. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil. Am J Clin Nutr 2002;76:1230-6.. View abstract.
Nagao T, Watanabe H, Goto N, et al. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr 2000;130:792-7.. View abstract.
Saito S, Takeshita M, Tomonobu K, et al. Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters. Nutrition 2006;22:174-8. View abstract.
Saito S, Tomonobu K, Hase T, Tokimitsu I. Effects of diacylglycerol on postprandial energy expenditure and respiratory quotient in healthy subjects. Nutrition 2006;22:30-5. View abstract.
Taguchi H, Watanabe H, Onizawa K, et al. Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J Am Coll Nutr 2000;19:789-96.. View abstract.
Takase H, Shoji K, Hase T, Tokimitsu I. Effect of diacylglycerol on postprandial lipid metabolism in non-diabetic subjects with and without insulin resistance. Atherosclerosis 2005;180:197-204. View abstract.
Tomonobu K, Hase T, Tokimitsu I. Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol. Nutrition 2006;22:128-35. View abstract.
US Food and Drug Administration. Center for Food Safety & Applied Nutrition. Office of Premarket Approval. Agency Response Letter GRAS Notice No. GRN 00056. DEcember 4, 2000 Available at: http://vm.cfsan.fda.gov/~rdb/opa-g056.html
Watanabe H, Onizawa K, Naito S, et al. Fat-soluble vitamin status is not affected by diacylglycerol consumption. Ann Nutr Metab 2001;45:259-64.. View abstract.
Yamamoto K, Asakawa H, Tokunaga K, et al. Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type II diabetic patients with hypertriglyceridemia. J Nutr 2001;131:3204-7.. View abstract.
Yamamoto K, Tomonobu K, Asakawa H, et al. Diet therapy with diacylglycerol oil delays the progression of renal failure in type 2 diabetic patients with nephropathy. Diabetes Care 2006;29:417-9. View abstract.
Yasunaga K, Glinsmann WH, Seo Y, et al. Safety aspects regarding the consumption of high-dose dietary diacylglycerol oil in men and women in a double-blind controlled trial in comparison with consumption of a triacylglycerol control oil. Food Chem Toxicol 2004;42:1419-29. View abstract.