Diclegis vs. Phenergan

Reviewed on 9/9/2019

Are Diclegis and Phenergan the Same Thing?

Zofran (ondansetron) and Phenergan (promethazine HCI) are used to prevent and treat nausea and vomiting after surgery.

Zofran is also used to treat nausea and vomiting due to cancer chemotherapy.

Phenergan is also used to treat nausea and vomiting related to motion sickness, and to treat allergic symptoms such as rash, itching, and runny nose.

The brand name Phenergan is discontinued in the U.S. Phenergan is available as a generic drug.

Zofran and Phenergan belong to different drug classes. Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Phenergan is an antihistamine.

Side effects of Zofran and Phenergan that are similar include dizziness, drowsiness, constipation, and blurred vision.

Side effects of Zofran that are different from Phenergan include diarrhea, headache, fever, lightheadedness, weakness, tiredness, rash, and muscle spasm.

Side effects of Phenergan that are different from Zofran include anxiety, dry mouth, stuffy nose, ringing in your ears, weight gain, swelling in your hands or feet, impotence, and trouble having an orgasm.

Both Zofran and Phenergan may interact with antidepressants, narcotics, and seizure medications.

Zofran may also interact with arsenic trioxide, tacrolimus, tramadol, antibiotics, anti-malaria medications, heart rhythm medicines, medicine to prevent or treat nausea and vomiting, medicines to treat psychiatric disorders, and migraine headache medicines.

Phenergan may also interact with cold or allergy medicines, sedatives, sleeping pills, muscle relaxers, anxiety medicines, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome medications, medicines to treat pituitary gland tumor, or medicines to treat stomach ulcer or irritable bowel syndrome.

What Are Possible Side Effects of Diclegis?

Side effects of Diclegis include:

Diclegis should be used with caution, especially with respect to activities that require complete mental alertness.

What Are Possible Side Effects of Phenergan?

Common side effects of Phenergan include:

  • drowsiness,
  • dizziness,
  • anxiety,
  • blurred vision,
  • dry mouth,
  • stuffy nose,
  • ringing in your ears,
  • weight gain,
  • swelling in your hands or feet,
  • impotence,
  • trouble having an orgasm, or
  • constipation.

What Is Diclegis?

Diclegis (doxylamine succinate and pyridoxine hydrochloride) is an antiemetic (anti-nausea and vomiting) agent used to treat nausea and vomiting in pregnant women.

What Is Phenergan?

Phenergan (promethazine HCI) is an antihistamine used to treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). Phenergan is also used to treat allergic symptoms such as rash, itching, and runny nose. The brand name Phenergan is discontinued in the U.S. Phenergan is available as a generic drug.

QUESTION

Nothing can relieve the symptoms of morning sickness. See Answer

What Drugs Interact With Diclegis?

Severe drowsiness can occur when using Diclegis with other sedative medications. Diclegis interacts with monoamine oxidase inhibitors (MAOIs), or alcohol and other CNS depressants (such as hypnotic sedatives and tranquilizers). Tell your doctor all medications and supplements you use. Diclegis is intended for use in pregnant women. Women should not breastfeed while using Diclegis.

What Drugs Interact With Phenergan?

Phenergan may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, seizure medications, antidepressants, anxiety medicines, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome medications, medicines to treat pituitary gland tumor, or medicines to treat stomach ulcer or irritable bowel syndrome. Tell your doctor all medications and supplements you use. Phenergan Tablets and Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Phenergan is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Phenergan Tablets and Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

How Should Diclegis Be Taken?

Diclegis are available as delayed-release tablets containing 10 mg doxylamine succinate and 10 mg pyridoxine hydrochloride. Patients should take two tablets of Diclegis at bedtime. If nausea and vomiting is not controlled with two tablets, the dose may be increased to a maximum of four tablets daily. Diclegis should not be used by women with sensitivities to any ingredient in Diclegis.

How Should Phenergan Be Taken?

The dose of Phenergan to treat allergies is 25 mg taken before retiring. The adult dose of Phenergan to treat motion sickness is 25 mg taken twice daily. The dose of Phenergan for the active therapy of nausea and vomiting in children or adults is 25 mg.

SLIDESHOW

13 Early Signs & Symptoms of Pregnancy See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References


Duchesnay USA Inc. Diclegis Product Monograph.

https://www.diclegis.com/en/

DailyMed. Phenergan Product Information.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6f7e47cc-f823-4336-8107-f980e3049617

Health Solutions From Our Sponsors