What Is Dicyclomine and How Does It Work?

Dicyclomine is used to treat a certain type of intestinal problem called irritable bowel syndrome. It helps to reduce the symptoms of stomach and intestinal cramping. This medication works by slowing the natural movements of the gut and by relaxing the muscles in the stomach and intestines. Dicyclomine belongs to a class of drugs known as anticholinergics/antispasmodics.

Dicyclomine must not be used in children younger than 6 months old because of the risk of serious side effects.

Dicyclomine is available under the following different brand names: Bentyl.

What Are Dosages of Dicyclomine?

Dosages of Dicyclomine:

Adult and Pediatric Dosage Forms and Strengths


  • 10 mg

Injectable Solution

  • 10 mg/mL


  • 10 mg/5 mL


  • 20 mg

Dosage Considerations – Should be Given as Follows:

Irritable Bowel Syndrome

Pediatric (Off-label)

  • 20 mg orally every 6 hours; may increase up to 40 mg every 6 hours; if efficacy not achieved in 2 weeks or adverse effects require dose less than 80 mg/day, therapy should be discontinued; safety data not available for doses greater than 80 mg/day for periods longer than 2 weeks
  • 10-20 mg intramuscularly (IM) every 6 hours; not to exceed 80 mg/day IM

Dosing considerations

  • IM use should not be longer than 1-2 days; replace IM with oral as soon as possible
  • Do not use intravenously (IV)
  • Infants older than 6 months: 5 mg orally every 6-8 hours; not to exceed 20 mg/day orally
  • Children: 10 mg orally every 6-8 hours; not to exceed 40 mg/day orally
  • Geriatric: 10-20 mg orally every 6 hours; may gradually increase as needed; not to exceed 160 mg/day


  • Take 30-60 minutes before a meal

Dosing considerations

  • Geriatric: High incidence of anticholinergic effects; avoid except in short-term situations to decrease secretions (Beers Criteria)
  • Do not use IM in geriatric patients

What Are Side Effects Associated with Using Dicyclomine?

Side effects associated with the use of Dicyclomine, include the following:

  • Dizziness
  • Dry mouth
  • Blurred vision
  • Drowsiness
  • Nervousness
  • Weakness

Other side effects of dicyclomine include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Dicyclomine?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

Severe Interactions of dicyclomine include:

  • None

Serious Interactions of dicyclomine include:

  • pramlintide

Dicyclomine has moderate interactions with at least 106 different drugs.

Mild Interactions of dicyclomine include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Dicyclomine?


  • This medication contains dicyclomine. Do not take Bentyl if you are allergic to dicyclomine or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately


Effects of Drug Abuse

  • No information provided

Short-Term Effects

  • See "What Are Side Effects Associated with Using Dicyclomine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Dicyclomine?"


Pregnancy and Lactation

  • Dicyclomine may be acceptable for use during pregnancy
  • Either animal studies show no risk but human studies are not available, or animal studies showed minor risks, and human studies were done and showed no risk.
  • Dicyclomine enters breast milk; its use is contraindicated if breastfeeding
Medscape. Dicyclomine.

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