Dienestrol Side Effects Center

Last updated on RxList: 8/9/2022
Dienestrol Side Effects Center

What Is Dienestrol?

Ortho Dienestrol Cream (dienestrol) is a form of the female hormone estrogen used to treat atrophic vaginitis and kraurosis vulvae. The brand name Ortho Dienestrol Cream is discontinued, but generic versions may be available.

What Are Side Effects of Dienestrol?

Common side effects of Ortho Dienestrol Cream (dienestrol) include:

  • vaginal irritation
  • dizziness
  • lightheadedness
  • headache
  • stomach upset
  • bloating
  • nausea
  • weight changes
  • increased/decreased interest in sex, and
  • breast tenderness

Dienestrol may cause serious side effects including:

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Dienestrol

The lowest dose of Ortho Dienestrol Cream that will control symptoms should be chosen and medication should be discontinued as promptly as possible.

What Drugs, Substances, or Supplements Interact with Dienestrol?

Ortho Dienestrol Cream may interact with other drugs. Tell your doctor all medications and supplements you use.

Dienestrol During Pregnancy or Breastfeeding

Estrogens may cause fetal harm when administered to a pregnant woman. Ortho Dienestrol Cream is not recommended for use during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information


Our Ortho Dienestrol Cream (dienestrol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Dienestrol Consumer Information
SIDE EFFECTS: Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


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Dienestrol Professional Information


(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gall bladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism.) The following additional adverse reactions have been reported with estrogenic therapy, including oral contraceptives:

1. Genitourinary system.

    Increase in size of uterine fibromyomata.
    Vaginal candidiasis.
    Breakthrough bleeding, spotting, change in menstrual flow.
    Dysmenorrhea. Premenstrual-like syndrome.
    Amenorrhea during and after treatment.
    Change in cervical eversion and in degree of cervical secretion.
    Cystitis-like syndrome.

2. Breasts.

    Tenderness, enlargement, secretion.

3. Gastrointestinal.

    Cholestatic jaundice.
    Nausea, vomiting.
    Abdominal cramps, bloating.

4. Skin.

5. Eyes.

    Steepening of corneal curvature.
    Intolerance to contact lenses.

6. CNS.

7. Miscellaneous.

Read the entire FDA prescribing information for Dienestrol (Dienestrol)

© Dienestrol Patient Information is supplied by Cerner Multum, Inc. and Dienestrol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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