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Disalcid

Last reviewed on RxList: 1/12/2018
Disalcid Side Effects Center

Last reviewed on RxList 1/12/2018

Disalcid (salsalate) is a nonsteroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates used to reduce pain, swelling, and joint stiffness caused by arthritis. The brand name Disalcid is no longer available in the U.S. Generic versions may be available. Common side effects of Disalcid (salsalate) include:

  • upset stomach,
  • heartburn, or
  • mild dizziness.

Tell your doctor if you have serious side effects of Disalcid (salsalate) including:

  • chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;
  • sudden numbness or weakness, especially on one side of the body;
  • feeling like you might pass out;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • hearing problems, ringing in your ears;
  • swelling in your hands or feet, rapid weight gain;
  • fast or pounding heartbeats;
  • easy bruising or bleeding, fever, chills, sore throat, flu symptoms;
  • urinating more or less than usual;
  • severe stomach pain, ongoing nausea or vomiting; or
  • dark urine, jaundice (yellowing of the skin or eyes).

The usual adult dosage of salsalate is 3000 mg daily, given in divided doses as: two doses of two 750 mg tablets; OR two doses of three 500 mg tablets/capsules; OR three doses of two 500 mg tablets/capsules. Salsalate may interact with acetazolamide, cyclosporine, lithium, methotrexate, pemetrexed, tenofovir, antidepressants, blood thinners, oral diabetes medications, diuretics (water pills), gout medications, heart or blood pressure medications, medication used to prevent blood clots, medicine to treat or prevent osteoporosis, sodium bicarbonate, potassium citrate, sodium citrate, citric acid, sodium citrate and potassium, seizure medications, or steroids. Tell your doctor all medications and supplements you use. During pregnancy, salsalate should be taken only if prescribed. It may be harmful to a fetus if the mother takes the medication during the last 3 months of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Salsalate can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Disalcid (salsalate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

The term arthritis refers to stiffness in the joints. See Answer
Disalcid Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop using salsalate and call your doctor at once if you have:

  • swelling in your hands or feet, rapid weight gain;
  • severe headache, blurred vision, pounding in your neck or ears;
  • pale skin, unusual tiredness, cold hands and feet;
  • liver problems--nausea, stomach pain (upper right side), tiredness, itching, jaundice (yellowing of the skin or eyes);
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems.

Older adults may be more likely to have side effects from salsalate.

Common side effects may include:

  • nausea;
  • hearing problems;
  • a spinning sensation;
  • rash; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Disalcid (Salsalate)

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Rheumatoid Arthritis (RA) Symptoms & Treatment See Slideshow
Disalcid Professional Information

SIDE EFFECTS

In two well-controlled clinical trials (n= 280 patients), the following reversible adverse experiences characteristic of salicylates were most commonly reported with DISALCID (salsalate) , listed in descending order of frequency: tinnitus, nausea, hearing impairment, rash, and vertigo. These common symptoms of salicylates, i.e., tinnitus or reversible hearing impairment, are often used as a guide to therapy.

Although cause-and-effect relationships have not been established, spontaneous reports over a ten-year period have included the following additional medically significant adverse experiences: abdominal pain, abnormal hepatic function, anaphylactic shock, angioedema, bronchospasm, decreased creatinine dearance, diarrhea, G.I. bleeding, hepatitis, hypotension, nephritis and urticaria.

DRUG ABUSE AND DEPENDENCE

Drug abuse and dependence have not been reported with DISALCID (salsalate) .

Read the entire FDA prescribing information for Disalcid (Salsalate)

Related Resources for Disalcid

Related Health

© Disalcid Patient Information is supplied by Cerner Multum, Inc. and Disalcid Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

QUESTION

The term arthritis refers to stiffness in the joints. See Answer

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